848738-27-2Relevant articles and documents
Ag-Catalyzed or Ag/PPh3-Catalyzed Chemoselective Switchable Cascade Reactions of N-Propargyl Thiocarbamoyl Fluorides and Malonate Esters
Cai, Zhongliang,Zhou, Junyi,Yu, Miao,Jiang, Liqin
supporting information, p. 293 - 298 (2022/01/12)
The divergent chemoselective synthesis of 2-methylene-2,3-dihydrothiazoles and 4-benzylidene pyrrolidine-2-thiones (most with E stereoselectivity) from N-propargyl thiocarbamoyl fluorides and malonate esters in moderate to excellent yields with a broad substrate scope and functional group tolerance has been accomplished. AgNTf2 catalyst at 60 °C in dichloroethane provided 4-benzylidene pyrrolidine-2-thiones. AgOTf catalyst and PPh3 ligand in refluxing acetonitrile resulted in a complete switch in the reactivity of formed α,α-diester thioamide intermediates followed by isomerization to access 2-methylene-2,3-dihydrothiazoles.
Synthesis of substituted quinolines by electrophilic cyclization of N-(2-alkynyl)anilines
Zhang, Xiaoxia,Campo, Marino A.,Yao, Tuanli,Larock, Richard C.
, p. 763 - 766 (2007/10/03)
(Chemical Equation Presented) Quinolines substituted in the 3-position by an iodo or phenylseleno group are readily prepared in good to excellent yields by the reaction of propargylic anilines with appropriate electrophiles under mild reaction conditions.