849794-02-1Relevant articles and documents
Molecular interactions of zinc(II) cyclams with polycarboxylato ligands
Jo, Hyejeong,Lough, Alan J.,Kim, Ju Chang
, p. 1274 - 1278 (2005)
Four new zinc(II) cyclams of the composition {Zn(L)(tp2-) ? H2O}n (1), {Zn(L)(H2bta2-) ? 2H2O}n (2), [Zn2(L)2(ox 2-)] 2ClO4 ? 2DMF (3), and Zn(L)(H 2btc-)2 ? 2DMF (4), where L = cyclam, tp2- = 1,4-benzenedicarboxylate ion, H2bta2- = 1,2,4,5-benzenetetracarboxylate ion, ox2- = oxalate ion, DMF = N,N-dimethylformamide, and H2btc- = 1,3,5- benzenetricarboxylate ion, have been synthesized and structurally characterized by a combination of analytical, spectroscopic and crystallographic methods. The carboxylato ligands in the complexes 1-4 show strong coordination tendencies toward zinc(II) cyclams with hydrogen bonding interactions between the pre-organized N-H groups of the macrocycle and oxygen atoms of the carboxylato ligands. The macrocycles in 1, 2, and 4 adopt trans-III configurations with the appropriate R,R,S,S arrangement of the four chiral nitrogen centers, respectively. However, the complex 3 shows an unusual cis V conformation with the R,R,R,R nitrogen configuration. The finding of strong interactions between the carboxylato ligands and the zinc(II) ions may provide additional knowledge for the improved design of receptor-targeted zinc(II) cyclams in anti-HIV agents.
