86-21-5Relevant articles and documents
Metal-Organic Framework with Dual Active Sites in Engineered Mesopores for Bioinspired Synergistic Catalysis
Quan, Yangjian,Song, Yang,Shi, Wenjie,Xu, Ziwan,Chen, Justin S.,Jiang, Xiaomin,Wang, Cheng,Lin, Wenbin
supporting information, p. 8602 - 8607 (2020/05/13)
Here we report the design of an enzyme-inspired metal-organic framework (MOF), 1-OTf-Ir, by installing strong Lewis acid and photoredox sites in engineered mesopores. Al-MOF (1), with mixed 2,2′-bipyridyl-5,5-dicarboxylate (dcbpy) and 1,4-benzenediacrylat
A synthetic method of pheniramine maleate
-
, (2018/07/06)
A novel synthetic method of pheniramine maleate is provided. The method includes subjecting benzylboronic acid and 2-halogenpyridine to a condensation reaction to obtain 2-benzylpyridine, subjecting the 2-benzylpyridine and 2-dimethylaminoethyl halide hydrochloride to a substitution reaction to prepare pheniramine, and salifying the pheniramine with maleic acid to obtain the pheniramine maleate. The method is simple in process, high in yield, low in cost and easy in industrial production.
Ruthenium-catalyzed /V-alkylation of amines and sulfonamides using borrowing hydrogen methodology
Hamid, M. Haniti S. A.,Allen, C. Liana,Lamb, Gareth W.,Maxwell, Aoife C.,Maytum, Hannah C.,et al.
supporting information; experimental part, p. 1766 - 1774 (2009/07/25)
The alkylation of amines by alcohols has been achieved using 0.5 mol percent [Ru(p-cymene)CI2]2 with the bidentate phosphines dppf or DPEphos as the catalyst. Primary amines have been converted into secondary amines, and secondary amines into tertiary amines, including the syntheses of Piribedil, Tripelennamine, and Chlorpheniramine. A/-Heterocyclization reactions of primary amines are reported, as well as alkylation reactions of primary sulfonamides. Secondary alcohols requiremore forcing conditions than primary alcohols but are still effective a lkylating agents in the presence of this catalyst.