863036-86-6

Basic information

• Product Name: ethyl 2-cinnamamido-2-hydroxyacetate
• Synonyms: ethyl 2-cinnamamido-2-hydroxyacetate
• CAS NO: 863036-86-6
• Molecular Weight: 249.266
• Mol File: 863036-86-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ethyl 2-cinnamamido-2-hydroxyacetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-cinnamamido-2-hydroxyacetate(863036-86-6)
• EPA Substance Registry System: ethyl 2-cinnamamido-2-hydroxyacetate(863036-86-6)

Safety Data

• Hazardous Substances Data: 863036-86-6(Hazardous Substances Data)

Upstream product

• 924-44-7 glyoxylic acid ethyl ester 
• 621-79-4 cinnamamide 

Downstream Products

• 863036-30-0 [(E)-(3-Phenyl-acryloyl)amino]-(3-pyridin-2-yl-thioureido)-acetic acid ethyl ester 
• 863036-31-1 N-[2-hydroxy-1-(3-pyridin-2-yl-thioureido)-ethyl]-3-phenyl-acrylamide 
• 863036-90-2 Amino-[(E)-(3-phenyl-acryloyl)amino]-acetic acid ethyl ester 

Relevant articles and documents

A direct route to 2-alkyl-4-carbethoxy-5-vinyloxazoles

The reaction of an α-chloroglycinate ester with the dimethylaluminum acetylide derivative of phenyl propargyl ether provides the corresponding 5-vinyloxazole in 40-50% yield.

Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative

The synthesis and structure-activity relationships (SAR) of salubrinal, a small molecule that protects cells from apoptosis induced by endoplasmic reticulum (ER) stress, are described. It is revealed that the trichloromethyl group greatly contributes to the activity. Based on the SAR results, salubrinal was converted into a biotinylated derivative which retains activity and can be used as a biological tool for target identification.