863870-77-3

Basic information

• Product Name: 3-CHLORO-2-IODOPHENYL N,N-DIETHYLCARBAMATE
• Synonyms: 3-CHLORO-2-IODOPHENYL N,N-DIETHYLCARBAMATE;3-CHLORO-2-IODOPHENYL N,N-DIETHYLCARBAMATE(WXG02757)
• CAS NO: 863870-77-3
• Molecular Formula: C₁₁H₁₃ClINO₂
• Molecular Weight: 353.58
• Product Categories: pharmacetical
• Mol File: 863870-77-3.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 371.3°C at 760 mmHg
• Flash Point: 178.4°C
• Appearance: /
• Density: 1.622g/cm³
• Vapor Pressure: 1.04E-05mmHg at 25°C
• Refractive Index: 1.585
• CAS DataBase Reference: 3-CHLORO-2-IODOPHENYL N,N-DIETHYLCARBAMATE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-2-IODOPHENYL N,N-DIETHYLCARBAMATE(863870-77-3)
• EPA Substance Registry System: 3-CHLORO-2-IODOPHENYL N,N-DIETHYLCARBAMATE(863870-77-3)

Safety Data

• Hazardous Substances Data: 863870-77-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H13ClINO2/c1-3-14(4-2)11(15)16-9-7-5-6-8(12)10(9)13/h5-7H,3-4H2,1-2H3

Upstream product

• 108-43-0 3-monochlorophenol 
• 88-10-8 N,N-diethylcarbamyl chloride 
• 159390-33-7 3-chlorophenyl N,N-diethylcarbamate 

Downstream Products

• 1154740-50-7 C₁₄H₁₆ClNO₃ 
• 1225288-06-1 2-bromo-3-chloro-6-iodophenyl N,N-diethyl O-carbamate 
• 25235-85-2 4-chloro-1H-indole 
• 70237-25-1 3-chloro-2-iodobenzenamine 
• 108-42-9 3-chloro-aniline 
• 1244651-45-3 N-(3-chloro-2-(hex-1-ynyl)phenyl)-2-hydroxy-2-methylpropanamide 
• 1244651-49-7 N-(3-chloro-2-(hept-1-ynyl)phenyl)-2-hydroxy-2-methylpropanamide 
• 1244651-54-4 N-(3-chloro-2-(2-(trimethylsilyl)ethynyl)phenyl)-2-hydroxy-2-methylpropanamide 
• 1244652-07-0 4-chloro-2-(3-chlorophenyl)-1H-indole 
• 1244651-34-0 N-(3-chloro-2-iodophenyl)-2-hydroxy-2-methylpropanamide 
• 1287792-07-7 2-butyl-4-chloro-3-(phenylthio)-1H-indole 
• 1287791-66-5 2-(3-chloro-2-iodophenoxy)-2-methylpropanamide 
• 1009093-35-9 C₈H₆ClIO₂ 
• 1009093-36-0 C₈H₉ClINO₂ 

Relevant articles and documents

KINASE INHIBITOR

[Problem] To provide a novel PIM-3 inhibitor and a novel cancer therapeutic drug, in particular, a therapeutic drug for pancreatic cancer. [Solution] A PIM-3 kinase inhibitor comprising a compound represented by general formula (I) or a pharmacologically acceptable salt, hydrate or solvate thereof.

THIENO [2, 3-B] PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS

The present invention relates to a series of compounds of formula (A) having antiviral activity, more specifically HIV (Human Immunodeficiency Virus) replication inhibiting properties. The invention also relates to methods for the preparation of such compounds, as well as to novel intermediates useful in one or more steps of such syntheses. The invention also relates to pharmaceutical compositions comprising an effective amount of such compounds as active ingredients. This invention further relates to the use of such compounds as medicines or in the manufacture of a medicament useful for the treatment of animals suffering from viral infections, in particular HIV infection. This invention further relates to methods for the treatment of viral infections in animals by the administration of a therapeutical amount of such compounds, optionally combined with one or more other drugs having anti-viral activity.

Synthesis of 4-functionalized-1H-indoles from 2,3-dihalophenols

A new synthesis of 4-halo-1H-indoles has been developed from easily available 2,3-dihalophenol derivatives. The key steps are Smiles rearrangement and a one-pot or stepwise Sonogashira coupling/NaOH-mediated cyclization. Subsequent functionalization allows access to a wide variety of 2,4- or 2,3,4-regioselectively functionalized indoles.