866206-55-5

Basic information

• Product Name: PRX-08066
• Synonyms: 5-[[4-[(6-Chlorothieno[2,3-d]pyrimidin-4-yl)amino]-1-piperidinyl]methyl]-2-fluoro-benzonitrile (2Z)-2-butenedioate (1:1);PRX-08066 Maleic acid;Benzonitrile, 5-[[4-[(6-chlorothieno[2,3-d]pyrimidin-4-yl)amino]-1-piperidinyl]methyl]-2-fluoro-, (2Z)-2-butenedioate (1:1)
• CAS NO: 866206-55-5
• Molecular Formula: C23H21ClFN5O4S
• Molecular Weight: 517.9603432
• Product Categories: Inhibitors
• Mol File: 866206-55-5.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Solubility: Soluble in DMSO
• CAS DataBase Reference: PRX-08066(CAS DataBase Reference)
• NIST Chemistry Reference: PRX-08066(866206-55-5)
• EPA Substance Registry System: PRX-08066(866206-55-5)

Safety Data

• Hazardous Substances Data: 866206-55-5(Hazardous Substances Data)

Usage

Description

PRX-08066, also known as Maleic acid, is a selective 5-HT2BR antagonist with high selectivity over closely related 5-HT2A and 5-HT2C receptors and other receptor targets.

Uses

Used in Pharmaceutical Industry:
PRX-08066 is used as a selective 5-HT2BR antagonist for treating various conditions related to the 5-HT2BR receptor, such as psychiatric and neurological disorders. Its high selectivity over other closely related receptors allows for targeted treatment with reduced side effects.
Used in Research Applications:
PRX-08066 is used as a research tool for studying the role of the 5-HT2BR receptor in various biological processes and for identifying potential drug candidates targeting this receptor. Its high selectivity makes it a valuable asset in research settings.

Enzyme inhibitor

This selective 5-hydroxytryptamine (serotonin) receptor antagonist (FW = 517.96 g/mol; CAS = 866206-55-5), also named 5-((4-(6-chlorothieno[2,3- d]pyrimidin-4-ylamino)piperidin-1-yl)methyl)-2-fluorobenzonitrile, targets 5-HT2B (IC50 of 3.4 nM), showing high selectivity over the closely related 5-HT2A, 5-HT2C and other receptors and preventing the severity of pulmonary arterial hypertension in the monocrotaline (MCT)-induced rat pulmonary artery hypertension model. PRX-08066 significantly attenuates the elevation in pulmonary artery pressure and right ventricular hypertrophy, thereby improving cardiac function. Targeting the 5-5-HT2B receptor also appears be an effective antiproliferative and antifibrotic strategy for small intestinal neuroendocrine tumors (SI-NETs), because it inhibits tumor microenvironment fibroblasts as well as NET cells.