868662-47-9

Basic information

• Product Name: 1H-Pyrazol-5-ol, 1-(7-chloro-4-quinolinyl)-4,5-dihydro-3-(4-nitrophenyl)-5-(trifluoromethyl) -
• CAS NO: 868662-47-9
• Molecular Formula: C19H12ClF3N4O3
• Molecular Weight: 436.777
• Mol File: 868662-47-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazol-5-ol, 1-(7-chloro-4-quinolinyl)-4,5-dihydro-3-(4-nitrophenyl)-5-(trifluoromethyl) -(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazol-5-ol, 1-(7-chloro-4-quinolinyl)-4,5-dihydro-3-(4-nitrophenyl)-5-(trifluoromethyl) -(868662-47-9)
• EPA Substance Registry System: 1H-Pyrazol-5-ol, 1-(7-chloro-4-quinolinyl)-4,5-dihydro-3-(4-nitrophenyl)-5-(trifluoromethyl) -(868662-47-9)

Safety Data

• Hazardous Substances Data: 868662-47-9(Hazardous Substances Data)

Upstream product

• 23834-14-2 7-chloro-4-hydrazinoquinoline 
• 164470-92-2 (Z)-1,1,1-trifluoro-4-methoxy-4-(4-nitrophenyl)but-3-en-2-one 
• 100-19-6 (4-nitrophenyl)ethanone 
• 53577-98-3 1-(1,1-dimethoxyethyl)-4-nitrobenzene 

Relevant articles and documents

Antimalarial activity of 4-(5-trifluoromethyl-1H-pyrazol-1-yl)-chloroquine analogues

The antimalarial activity of chloroquine-pyrazole analogues, synthesized from the reaction of 1,1,1-trifluoro-4-methoxy-3-alken-2-ones with 4-hydrazino-7-chloroquinoline, has been evaluated in vitro against a chloroquine resistant Plasmodium falciparum clone. Parasite growth in the presence of the test drugs was measured by incorporation of [3H]hypoxanthine in comparison to controls with no drugs. All but one of the eight (4,5-dihydropyrazol-1-yl) chloroquine 2 derivatives tested showed a significant activity in vitro, thus, are a promising new class of antimalarials. The three most active ones were also tested in vivo against Plasmodium berghei in mice. However, the (pyrazol-1-yl) chloroquine 3 derivatives were mostly inactive, suggesting that the aromatic functionality of the pyrazole ring was critical.