873551-03-2

Basic information

• Product Name: (S)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine L-hydrogen tartrate
• Synonyms: (S)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine L-hydrogen tartrate
• CAS NO: 873551-03-2
• Molecular Weight: 475.582
• Mol File: 873551-03-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (S)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine L-hydrogen tartrate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine L-hydrogen tartrate(873551-03-2)
• EPA Substance Registry System: (S)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine L-hydrogen tartrate(873551-03-2)

Safety Data

• Hazardous Substances Data: 873551-03-2(Hazardous Substances Data)

Upstream product

• 87-69-4 L-Tartaric acid 
• 124936-74-9 N,N-diiso-propyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine 
• 897314-72-6 (+/-)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propanamide 
• 1043911-42-7 N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propylamine L-tartrate 
• 944241-58-1 racemic tolterodine hydrogen sulfate 

Relevant articles and documents

Process for the preparation of N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)- 3-phenyl propylamine and its salts starting from a novel intermediate

The invention concerns an improved process for the preparation of tolterodine (N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl propylamine) and its salts, in particular for the preparation of the tartrate salt, and more in particular for the (+)-(R) enantiomer of tolterodine L-tartrate, starting from a novel intermediate, N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-2-propenamide which can be used as pure Z or E isomer or as a mixture of Z and E isomers.

A process for the purification of tolterodine

Process for the purification of tolterodine comprising reacting racemic tolterodine with sulfuric acid to obtain an addition salt and racemic tolterodine acid sulfate in the crystalline form.

TOLTERODINE, COMPOSITIONS AND USES THEREOF, AND PREPARATION OF THE SAME

Racemic tolterodine free base in crystalline form, tolterodine with improved purity, compositions and uses thereof, and processes of preparing the same.