879088-40-1

Basic information

• Product Name: 2-(2-chloro-5-nitrophenyl)pyridine
• Synonyms: 2-(2-chloro-5-nitrophenyl)pyridine;4-Chloro-3-(pyridin-2-yl)nitrobenzene;2-(2-chloro-5-nitrophenyl)pyridine hydrochloride
• CAS NO: 879088-40-1
• Molecular Formula: C₁₁H₇ClN₂O₂
• Molecular Weight: 235
• Mol File: 879088-40-1.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-(2-chloro-5-nitrophenyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-chloro-5-nitrophenyl)pyridine(879088-40-1)
• EPA Substance Registry System: 2-(2-chloro-5-nitrophenyl)pyridine(879088-40-1)

Safety Data

• Hazardous Substances Data: 879088-40-1(Hazardous Substances Data)

Usage

Description

2-(2-chloro-5-nitrophenyl)pyridine is an organic compound that serves as a key intermediate in the synthesis of pharmaceuticals, particularly in the development of hedgehog pathway inhibitors.
Used in Pharmaceutical Industry:
2-(2-chloro-5-nitrophenyl)pyridine is used as a chemical intermediate for the synthesis of Vismondegib (V674700), a hedgehog pathway inhibitor. 2-(2-chloro-5-nitrophenyl)pyridine plays a crucial role in the development of medications targeting the hedgehog signaling pathway, which is implicated in various diseases, including cancer and congenital disorders.

Upstream product

• 74534-15-9 1-chloro-2-iodo-4-nitrobenzene 
• 874186-98-8 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 
• 13331-27-6 m-nitrobenzene boronic acid 
• 68716-48-3 4,4,5,5-tetramethyl-2-(3-nitrophenyl)-1,3,2-dioxaborolane 
• 585-79-5 m-nitrobromobenzene 
• 197958-29-5 pyridin-2-ylboronic acid 
• 23082-50-0 2'-chloro-5'-nitroacetophenone 
• 16588-26-4 3-bromo-4-chloronitrobenzene 
• 81745-83-7 pyridin-2-ylzinc(ll) bromide 
• 109-76-2 Trimethylenediamine 
• 675-20-7 piperidin-2-one 
• 2142-68-9 1-(2-chlorophenyl)ethanone 
• 4381-32-2 2-(2-chlorophenyl)pyridine 
• 694-80-4 2-bromo-1-chlorobenzene 

Downstream Products

• 879085-55-9 vismodegib 
• 879088-41-2 4-chloro-3-(pyridin-2-yl)benzeneamine 

Relevant articles and documents

Preparation method of vimodegil

The invention provides a preparation method of vimodegil. 2-chloro-5-nitroacetophenone is used as a raw material; 5-oxo-5-(2-chloro-5-nitrophenyl) n-valeraldehyde is prepared through an addition reaction between 2-chloro-5-nitroacetophenone and acrolein,

Selective Late-Stage Oxygenation of Sulfides with Ground-State Oxygen by Uranyl Photocatalysis

Oxygenation is a fundamental transformation in synthesis. Herein, we describe the selective late-stage oxygenation of sulfur-containing complex molecules with ground-state oxygen under ambient conditions. The high oxidation potential of the active uranyl cation (UO22+) enabled the efficient synthesis of sulfones. The ligand-to-metal charge transfer process (LMCT) from O 2p to U 5f within the O=U=O group, which generates a UV center and an oxygen radical, is assumed to be affected by the solvent and additives, and can be tuned to promote selective sulfoxidation. This tunable strategy enabled the batch synthesis of 32 pharmaceuticals and analogues by late-stage oxygenation in an atom- and step-efficient manner.

Preparation method of vismodegib

The invention relates to a preparation method of vismodegib. The preparation method of the vismodegib comprises the following steps: taking 2-chlorine-5-nitroacetophenone as a starting material, performing 1,4-addition reaction on the 2-chlorine-5-nitroac