88-32-4

Basic information

• Product Name: 2-TERT-BUTYL-4-HYDROXYANISOLE
• Synonyms: 3-TERT-BUTYL-4-METHOXYPHENOL;2-BHA;2-T-BUTYL-4-HYDROXYANISOLE;2-TERT-BUTYL-4-HYDROXYANISOLE;3-tert-Bha;3-tert-butyl-4-methoxy-pheno;3-tert-Butylated hydroxyanisole;3-tert-butylatedhydroxyanisole
• CAS NO: 88-32-4
• Molecular Formula: C₁₁H₁₆O₂
• Molecular Weight: 180.24
• EINECS: 201-820-3
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Isotope Labelled Compounds;Pharmaceuticals;Agro-Products
• Mol File: 88-32-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 64℃
• Boiling Point: 253.08°C (rough estimate)
• Flash Point: 136 °C
• Appearance: /
• Density: 0.9976 (rough estimate)
• Vapor Pressure: 0.000991mmHg at 25°C
• Refractive Index: 1.4708 (estimate)
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 10.58±0.18(Predicted)
• CAS DataBase Reference: 2-TERT-BUTYL-4-HYDROXYANISOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-TERT-BUTYL-4-HYDROXYANISOLE(88-32-4)
• EPA Substance Registry System: 2-TERT-BUTYL-4-HYDROXYANISOLE(88-32-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 88-32-4(Hazardous Substances Data)

Usage

Description

2-TERT-BUTYL-4-HYDROXYANISOLE, also known as BHT, is an aromatic ether that is 4-methoxyphenol in which one of the hydrogens ortho to the methoxy group is replaced by a tert-butyl group. It is a synthetic compound with antioxidant and anti-inflammatory properties.
Used in Pharmaceutical Industry:
2-TERT-BUTYL-4-HYDROXYANISOLE is used as an anticholinergic agent for its ability to block the action of acetylcholine, a neurotransmitter that plays a key role in the parasympathetic nervous system.
Used in Agriculture:
2-TERT-BUTYL-4-HYDROXYANISOLE is used as an insecticide for its insecticidal activity, helping to control and prevent infestations in crops and other agricultural settings.

Synthesis Reference(s)

Synthesis, p. 638, 1980 DOI: 10.1055/s-1980-29150

InChI:InChI=1/C11H16O2/c1-11(2,3)9-7-8(12)5-6-10(9)13-4/h5-7,12H,1-4H3

Upstream product

• 1991-52-2 2,5-di-tert-butyl-4-methoxyphenol 
• 21112-37-8 1,4-dimethoxy-2-tert-butylbenzene 
• 3421-95-2 4-(benzyloxy)-2-(tert-butyl)phenol 
• 77-78-1 dimethyl sulfate 
• 1948-33-0 tert-butylhydroquinone 
• 70020-83-6 2-tert-Butyl-4-(tert-butyl-dimethyl-silanyloxy)-phenol 
• 70020-84-7 tert-Butyl-(3-tert-butyl-4-methoxy-phenoxy)-dimethyl-silane 
• 150-76-5 4-methoxy-phenol 
• 75-65-0 tert-butyl alcohol 
• 115-11-7 isobutene 

Downstream Products

• 5288-44-8 5,5'-di-tert-butyl-4,4'-dimethoxy-2,2'-methanediyl-di-phenol 
• 1911-86-0 5,5'-dimethoxy-4,4'-di-t-butylbiphenyl-2,2'-diol 
• 85013-44-1 2-hydroxy-2'-(2-hydroxy-5-methoxy-4-t-butylphenoxy)-5,5'-dimethoxy-4,4'-di-t-butylbiphenyl 
• 85013-43-0 4-methoxy-2-(4-methoxy-3-t-butylphenoxy)-5-t-butylphenol 
• 95323-87-8 3-tert.-Butyl-4-methoxy-phenoxyradikal 
• 1947-14-4 1,2,5-trimethoxy-4-tert-butylbenzene 
• 91352-66-8 4-tert-butyl-5-methoxycatechol 
• 1948-33-0 tert-butylhydroquinone 
• 1351258-69-9 4-(3-tert-butyl-4-methoxyphenoxy)phthalonitrile 
• 311337-21-0 C₁₇H₁₇Cl₂NO₄ 
• 121-00-6 3-tert-Butyl-4-hydroxyanisole 
• 1072073-04-1 2-allyl-5-tert-butyl-4-methoxyphenol 
• 131311-36-9 2-Allyl-6-tert-butyl-4-methoxy-phenol 
• 36122-03-9 4-tert-butyl-5-methoxy-1,2-benzoquinone 

Relevant articles and documents

Photocatalytic synthesis of dihydrobenzofurans by oxidative [3+2] cycloaddition of phenols

We report a protocol for oxidative [3+2] cycloadditions of phenols and alkenes applicable to the modular synthesis of a large family of dihydrobenzofuran natural products. Visible-light-activated transition metal photocatalysis enables the use of ammonium persulfate as an easily handled benign terminal oxidant. The broad range of organic substrates that are readily oxidized by photoredox catalysis suggests that this strategy may be applicable to a variety of useful oxidative transformations.

Process for preparing monoalkylethers of hydroquinone and its derivatives

A method for preparing monoalkylethers of hydroquinone and of substituted hydroquinones of general formula STR1 in which R is an alkyl group and R1 is hydrogen or an alkyl group, wherein a hydroquinone compound of general formula STR2 is reacted with an alcohol or formula R-OH in the presence of transition metal salts, either in the presence or in the absence of air or oxygen.

Synthesis and chemical carcinogen inhibitory activity of 2-tert-butyl-4-hydroxyanisole

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