88625-24-5

Basic information

• Product Name: 5-CHLOROPYRAZINE-2-CARBALDEHYDE
• Synonyms: 5-CHLOROPYRAZINE-2-CARBALDEHYDE;5-Chloro-2-pyrazinecarboxaldehyde;5-Chloropyrazine-2-carboxaldehyde;Pyrazinecarboxaldehyde, 5-chloro-;5-Chloro-pyrazinecarboxaldehyde
• CAS NO: 88625-24-5
• Molecular Formula: C5H3ClN2O
• Molecular Weight: 142.55
• EINECS: 1312995-182-4
• Mol File: 88625-24-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 221℃
• Flash Point: 88℃
• Appearance: /
• Density: 1.432
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -3.78±0.10(Predicted)
• CAS DataBase Reference: 5-CHLOROPYRAZINE-2-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLOROPYRAZINE-2-CARBALDEHYDE(88625-24-5)
• EPA Substance Registry System: 5-CHLOROPYRAZINE-2-CARBALDEHYDE(88625-24-5)

Safety Data

• Hazardous Substances Data: 88625-24-5(Hazardous Substances Data)

Usage

General Description

5-Chloropyrazine-2-carbaldehyde is a chemical compound with the molecular formula C5H3ClN2O. It is a yellow solid that is used in the synthesis of pharmaceuticals and agrochemicals. 5-CHLOROPYRAZINE-2-CARBALDEHYDE is also used as an intermediate in the production of other chemicals, including dyes and pigments. It is a versatile building block in organic chemistry and is known for its ability to undergo various reactions, including oxidation, reduction, and nucleophilic substitution. 5-Chloropyrazine-2-carbaldehyde is a key ingredient in the production of a wide range of products in the chemical industry.

Upstream product

• 72788-94-4 (5-chloro-2-pyrazinyl)methanol 
• 36070-80-1 5-chloropyrazinoic acid 
• 33332-25-1 methyl 5-chloropyrazine-2-carboxylate 

Downstream Products

• 72788-94-4 (5-chloro-2-pyrazinyl)methanol 

Relevant articles and documents

SUBSTITUTED BICYCLE HETEROCYCLIC DERIVATIVES USEFUL AS ROMK CHANNEL INHIBITORS

Disclosed are compounds of Formula (I) or a salt thereof, wherein R1 is (II) or (III); each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3, L1, L2, R1a, R1b, R1c, and n are define herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.

Benzoxaborole Antimalarial Agents. Part 4. Discovery of Potent 6-(2-(Alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles

A series of 6-hetaryloxy benzoxaborole compounds was designed and synthesized for a structure-activity relationship (SAR) investigation to assess the changes in antimalarial activity which result from 6-aryloxy structural variation, substituent modification on the pyrazine ring, and optimization of the side chain ester group. This SAR study discovered highly potent 6-(2-(alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles (9, 27-34) with IC50s = 0.2-22 nM against cultured Plasmodium falciparum W2 and 3D7 strains. Compound 9 also demonstrated excellent in vivo efficacy against P. berghei in infected mice (ED90 = 7.0 mg/kg).