90880-35-6

Basic information

• Product Name: NEUROPEPTIDE Y (HUMAN, RAT)
• Synonyms: NPY FREE ACID (HUMAN, RAT);NPY (HUMAN, RAT);NEUROPEPTIDE Y FREE ACID (HUMAN, RAT);NEUROPEPTIDE Y, HUMAN;NEUROPEPTIDE Y (HUMAN, RAT);TYP-PRO-SER-LYS-PRO-ASP-ASN-PRO-GLY-GLU-ASP-ALA-PRO-ALA-GLU-ASP-MET-ALA-ARG-TYR-TYR-SER-ALA-LEU-ARG-HIS-TYR-ILE-ASN-LEU-ILE-THR-ARG-GLN-ARG-TYR;YPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRY;H-TYR-PRO-SER-LYS-PRO-ASP-ASN-PRO-GLY-GLU-ASP-ALA-PRO-ALA-GLU-ASP-MET-ALA-ARG-TYR-TYR-SER-ALA-LEU-ARG-HIS-TYR-ILE-ASN-LEU-ILE-THR-ARG-GLN-ARG-TYR-OH
• CAS NO: 90880-35-6
• Molecular Formula: C189H284N55O57RS
• Molecular Weight: 4270.67656
• Product Categories: Neuropeptide Y (NPY ) receptor;Peptide Receptors;proteins
• Mol File: 90880-35-6.mol
• Article Data: 0

Chemical Properties

• Appearance: white/powder
• Storage Temp.: −20°C
• Solubility: H2O: 1 mg/mL
• CAS DataBase Reference: NEUROPEPTIDE Y (HUMAN, RAT)(CAS DataBase Reference)
• NIST Chemistry Reference: NEUROPEPTIDE Y (HUMAN, RAT)(90880-35-6)
• EPA Substance Registry System: NEUROPEPTIDE Y (HUMAN, RAT)(90880-35-6)

Safety Data

• WGK Germany: 3
• RTECS: QQ4064000
• F: 10-21
• Hazardous Substances Data: 90880-35-6(Hazardous Substances Data)

Usage

Description

Neuropeptide Y (NPY) is a peptide that is abundantly distributed throughout the central and peripheral nervous systems in both humans and rats. It plays a significant role in controlling various physiological processes, including appetite, blood pressure, cardiac contractility, and intestinal secretion. NPY interacts with five subtypes of its receptors, with Y1 and Y5 subtypes being involved in stimulating feeding, while Y2 and Y4 subtypes are associated with satiety. Additionally, NPY has been shown to interact with the immune system, promoting gastrointestinal inflammation and exhibiting antimicrobial effects against several gut bacteria.

Uses

Used in Neuroscience Research:
Neuropeptide Y (Human, Rat) is used as a research tool for studying the effects of NPY on various neurological processes, such as epilepsy, motor seizures, and electroencephalographic (EEG) seizures induced by kainic acid.
Used in Appetite Regulation Studies:
NPY is used as a research compound to investigate its role in appetite regulation and the stimulation of feeding through its interaction with Y1 and Y5 receptor subtypes.
Used in Satiety Research:
Neuropeptide Y (Human, Rat) is used as a research tool to study the roles of Y2 and Y4 receptor subtypes in satiety and their potential applications in the development of anti-obesity treatments.
Used in Immune System Research:
NPY is used as a research compound to explore its interactions with the immune system, its promotion of gastrointestinal inflammation, and its antimicrobial effects against gut bacteria.
Used in High-Performance Liquid Chromatography (HPLC):
Neuropeptide Y (Human) is used as a standard and control in HPLC to verify the specificity of antibodies, ensuring accurate and reliable results in various research applications.

Biochem/physiol Actions

Vasoconstrictor; brain peptide that inhibits Ca2+-activated K+ channels in vascular smooth muscle. Implicated in the control of blood pressure, sexual behavior and food intake. Inhibits cholecystokinin- and secretin-stimulated pancreatic secretion.