91714-51-1Relevant articles and documents
A preparation method of a bromfenac sodium sesquihydrate compound
-
Paragraph 0016; 0034; 0035; 0036, (2018/10/11)
A preparation method of a bromfenac sodium sesquihydrate compound is disclosed. The method includes steps of subjecting a compound of a formula 3 and an aqueous solution of sodium hydroxide to a hydrolysis reaction; directly subjecting the reaction solution to suction filtration after the reaction is completed; collecting a filtrate; adding sodium chloride or sodium bicarbonate into the filtrate;washing solid precipitated after the sodium chloride or sodium bicarbonate is added with saturated brine and acetone; performing recrystallization using a mixed solvent that is water/acetone, water/glycol dimethyl ether or water/ethylene glycol; and washing the solid obtained by recrystallization with acetone to obtain the bromfenac sodium sesquihydrate compound that is the compound of the formula4. The method is simple to operate and stable in process, and the obtained bromfenac sodium sesquihydrate compound is yellow solid with extremely high purity.