92-74-0Relevant articles and documents
Production method and system of naphthol AS series products
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Paragraph 0021; 0024; 0030, (2021/08/28)
The invention discloses a production method and system of naphthol AS series products. The specific steps are as follows: S1, taking chlorobenzene as a solvent for condensation reaction, dehydrating the chlorobenzene, adding the dehydrated chlorobenzene into a reactor, then adding raw material reactants of the naphthol AS series products, heating, raising the temperature, and dropwise adding phosphorus trichloride for condensation reaction; and S2, adding sodium carbonate and water into a distillation kettle, then introducing the condensed material in the S1 into the distillation kettle for heating and distilling, removing the solvent chlorobenzene, filtering the rest material, and carrying out flash evaporation drying on the filter cake to obtain the naphthol AS series products. The raw material reactants of the AS series products comprise a reactant A and a reactant B, wherein the reactant A is 2-hydroxy-3-naphthoic acid, and the reactant B can be o-aminophenetole, 2, 5-dimethoxy-4-chloroaniline, o-aminoanisole, parachloroaniline, o-toluidine, m-nitroaniline, menaphthylamine or 5-aminobenzimidazolone. Differentnaphthol AS series products can be obtained by selecting different reactants B according to needs.
Antimycobacterial N-alkoxyphenylhydroxynaphthalenecarboxamides affecting photosystem II
Gonec, Tomas,Kralova, Katarina,Pesko, Matus,Jampilek, Josef
, p. 1881 - 1885 (2017/04/07)
N-(Alkoxyphenyl)-2-hydroxynaphthalene-1-carboxamides (series A) and N-(alkoxyphenyl)-1-hydroxynaphthalene-2-carboxamides (series B) affecting photosystem (PS) II inhibited photosynthetic electron transport (PET) in spinach chloroplasts. Their inhibitory activity depended on the compound lipophilicity as well as on the position of the alkoxy substituent. The most potent PET inhibitors were 2-hydroxy-N-phenylnaphthalene-1-carboxamide and N-[3-(but-2-yloxy)phenyl]-2-hydroxynaphthalene-1-carboxamide within series A (IC50?=?28.9 and 42.5?μM, respectively) and 1-hydroxy-N-(3-propoxyphenyl)naphthalene-2-carboxamide and 1-hydroxy-N-(3-ethoxyphenyl)-naphthalene-2-carboxamide (IC50?=?2.0 and 3.1?μM, respectively) within series B. The inhibitory activity of C′(3) or C′(4) alkoxy substituted compounds of series B was considerably higher than that of C′(2) ones within series A. The PET-inhibiting activities of both series were compared with the PET inhibition of isomeric N-alkoxyphenyl-3-hydroxynaphthalene-2-carboxamides (series C) reported recently. Interactions of the studied compounds with chlorophyll a and aromatic amino acids present in pigment–protein complexes mainly in PS II were documented by fluorescence spectroscopy. The section between P680 and plastoquinone QB in the PET chain occurring on the acceptor side of PS?II can be suggested as the site of action of the compounds.
Process for the preparation of pure, aromatic o-hydroxy-carboxylic acid aryl amides
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, (2008/06/13)
Process for the preparation of pure aromatic o-hydroxy-carboxylic acid aryl amides by condensing an aromatic o-hydroxy-carboxylic acid with an aryl amine in the presence of phosphorus chlorides in an organic solvent or diluent, which process comprises treating the reaction mixture or the reaction product with 1 to 25 %, calculated on the weight of the reaction product, of an aliphatic amino-polycarboxylic acid as chelate forming agent. It is not necessary to purify the products, because they are obtained in such a pure form that they can be used directly as coupling components for azo pigments.