92433-53-9

Basic information

• Product Name: N-(2-(4-chlorobenzoyl)phenyl)acetamide
• Synonyms: N-(2-(4-chlorobenzoyl)phenyl)acetamide
• CAS NO: 92433-53-9
• Molecular Weight: 273.719
• Mol File: 92433-53-9.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: N-(2-(4-chlorobenzoyl)phenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-(4-chlorobenzoyl)phenyl)acetamide(92433-53-9)
• EPA Substance Registry System: N-(2-(4-chlorobenzoyl)phenyl)acetamide(92433-53-9)

Safety Data

• Hazardous Substances Data: 92433-53-9(Hazardous Substances Data)

Upstream product

• 7099-88-9 4-chlorophenylglyoxylic acid 
• 103-84-4 Acetanilid 
• 104-88-1 4-chlorobenzaldehyde 
• 62-53-3 aniline 
• 873-76-7 para-Chlorobenzyl alcohol 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 1885-29-6 anthranilic acid nitrile 
• 2894-51-1 2-amino-4'-chlorobenzophenone 
• 108-24-7 acetic anhydride 
• 99-91-2 para-chloroacetophenone 
• 19591-17-4 o-iodoacetanilide 
• 106-43-4 para-chlorotoluene 
• 15826-91-2 acetanilide-d5 

Downstream Products

• 113449-33-5 (biphenyl-2-yl)(4'-chlorophenyl)methanone 
• 2894-51-1 2-amino-4'-chlorobenzophenone 
• 105189-09-1 2-[4-(2-hydroxyethyl)-1-piperazinyl]-4-(4-chlorophenyl)quinoline 
• 105188-99-6 2-(4-ethyl-1-piperazinyl)-4-(4-chlorophenyl)quinoline 
• 105189-07-9 2-(1-piperazinyl)-4-(4-chlorophenyl)quinoline 
• 27309-46-2 2-chloro-4-(4-chloro-phenyl)-quinoline 
• 93501-08-7 4-(4-chlorophenyl)-2-quinolinone 

Relevant articles and documents

Bicyclic Bridgehead Phosphoramidite-Based Hybrid Diphosphorus Ligands: Design, Synthesis, and Application in Catalytic Asymmetric Hydrogenation

A strategy for chiral ligand design has been developed that allows for incorporation of an achiral bicyclic bridgehead phosphoramidite to generate a class of hybrid diphosphorus ligands for high activity and asymmetric control. Using this concept, a series of chiral phosphine-phosphoramidite ligands bearing the sole chirality at the ligand backbone have been prepared and successfully employed in the Rh-catalyzed asymmetric hydrogenation of 2-vinylanilides for the synthesis of optically active anilines bearing an ortho-tertiary benzylic stereocenter.

Palladium Catalyzed Direct Acylation of Iodo-Acetanilides/Iodo-Phenyl Acetates: Domino One-Pot Synthesis of 2-Quinolinones

Pd-catalyzed direct acylation reaction of iodoacetanilides/iodophenyl acetates with aldehydes is presented. Simple, bench-top aldehydes were used as non-toxic acylating agents. This protocol comprises direct coupling with aldehydes without activating the carbonyl group and without directing group assistance. The strategy was applied to a domino one-pot synthesis of 2-quinolinones through acylation and intramolecular aldol condensation. Significantly, the strategy was extended to the domino one-pot synthesis of drugs and bioactive compounds.

Dual role of acetanilides: Traceless removal of a directing group through deacetylation/diazotation and palladium-catalyzed C-C-coupling reactions

The acetamide group enables regioselective oxidative ortho-C-H activation reactions, such as Pd-catalyzed acylation. The synthetic utility of these transformations can be significantly enhanced by using the acetamide as a quasi-leaving group in a subsequent conventional Pd-catalyzed coupling or cross-coupling reaction. The concept is illustrated herein for the synthesis of o-alkenyl- and o-arylphenones, which have potential for the synthesis of arylated aromatic heterocycles.