935-04-6Relevant articles and documents
Direct Synthesis of Deuterium-Labeled O -, S -, N-Vinyl Derivatives from Calcium Carbide
Ananikov, Valentine P.,Egorova, Ksenia S.,Ledovskaya, Maria S.,Posvyatenko, Alexandra V.,Rodygin, Konstantin S.,Voronin, Vladimir V.
, p. 3001 - 3013 (2019)
A novel methodology for the preparation of trideuterovinyl derivatives of high purity directly from alcohols, thiols, and NH-compounds was developed. Commercially available calcium carbide and D 2 O acted as a D 2 -acetylene source, and DMSO- d 6 was used to complete the formation of the D 2 C=C(D)-X fragment (X = O, S, N). Polymerization of a selected trideuterovinylated compound showed a very promising potential of these substances in the synthesis of labeled polymeric materials. Biological activity of the synthesized trideuterovinyl derivatives was evaluated and the results indicated a significant increase of cytotoxicity upon deuteration.
Method for preparing benzyl vinyl ether and monomer copolymer thereof
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Paragraph 0044-0072; 0077-0083; 0086-0093; 0096-0103, (2020/06/05)
The invention belongs to the field of fine chemical synthesis, and relates to a method for preparing benzyl vinyl ether and a monomer copolymer thereof. Benzyl vinyl ether is prepared from benzyl alcohol and acetylene under the catalysis of a catalyst in a low-pressure, heating and stirring environment, and then hydroxyalkyl ether, fluoro-olefin and an initiator are added to prepare the benzyl vinyl ether copolymer. The yield of benzyl vinyl ether prepared by the method is as high as 51-85%, the purity is as high as 98.0%-99.9%, and the yield of the benzyl vinyl ether copolymer is 80%-99.5%. Moreover, production equipment of the preparation method is conventional equipment, the used catalyst is cheap, the catalyst is not easy to inactivate in the reaction process, reaction conditions are mild and easy to implement, operation is convenient, and the preparation method is suitable for industrial production.
Preparation method of bilastine intermediate
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Paragraph 0082-0083, (2020/02/10)
The invention relates to a preparation method of a bilastine intermediate represented by a formula 1. The preparation method specifically comprises: carrying out a reaction in a first solvent in the presence of DBU by using 2-bromoethyl anisole (formula I