942518-29-8

Basic information

• Product Name: 4-Azido-L-homoalanine, (S)-2-Amino-4-azidobutanoic acid hydrochloride
• Synonyms: 4-Azido-L-homoalanine, (S)-2-Amino-4-azidobutanoic acid hydrochloride;H-L-Aha-OH*HCl;(S)-2-Amino-4-azido-butanoic acid HCl;H-L-Aha-OH hydrochloride;4-Azido-L-homoalanine hydrochloride;(2S)-2-Amino-4-azidobutanoic acid hydrochloride (1:1);(S)-2-Amino-4-azidobutanoic acid hydrochloride;L-Dab(N3)-OH·HCl
• CAS NO: 942518-29-8
• Molecular Formula: C4H9ClN4O2
• Molecular Weight: 180.59286
• Mol File: 942518-29-8.mol
• Article Data: 0

Chemical Properties

• Melting Point: 139°C
• Appearance: /
• Storage Temp.: -20°C
• CAS DataBase Reference: 4-Azido-L-homoalanine, (S)-2-Amino-4-azidobutanoic acid hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Azido-L-homoalanine, (S)-2-Amino-4-azidobutanoic acid hydrochloride(942518-29-8)
• EPA Substance Registry System: 4-Azido-L-homoalanine, (S)-2-Amino-4-azidobutanoic acid hydrochloride(942518-29-8)

Safety Data

• Hazardous Substances Data: 942518-29-8(Hazardous Substances Data)

Usage

Description

4-Azido-L-homoalanine, (S)-2-Amino-4-azidobutanoic acid hydrochloride is an amino acid analog of methionine with a small modification, specifically an azido moiety. 4-Azido-L-homoalanine, (S)-2-Amino-4-azidobutanoic acid hydrochloride can be incorporated into proteins during active protein synthesis in cultured cells, allowing for chemoselective ligation or "click" reaction between the azide and an alkyne or cyclooctyne for detection purposes.

Uses

Used in Biochemistry Research:
4-Azido-L-homoalanine, (S)-2-Amino-4-azidobutanoic acid hydrochloride is used as a research tool for studying protein synthesis and detection in various applications. The incorporation of this compound into proteins allows for the use of fluorescent or biotin-tagged alkynes to detect and analyze proteins with high sensitivity in 1-D gels and Western blots, as well as compatibility with downstream LC-MS/MS and MALDI-MS analysis.
Used in Drug Development:
4-Azido-L-homoalanine, (S)-2-Amino-4-azidobutanoic acid hydrochloride can be employed in the development of drugs targeting specific proteins or pathways. By incorporating this compound into proteins of interest, researchers can study the effects of potential drug candidates on protein synthesis, function, and interactions, ultimately aiding in the discovery of novel therapeutic agents.
Used in Diagnostic Applications:
In the field of diagnostics, 4-Azido-L-homoalanine, (S)-2-Amino-4-azidobutanoic acid hydrochloride can be utilized for the development of assays and tests to detect and monitor specific proteins or protein modifications. The high sensitivity and compatibility with various detection methods make it a valuable tool for the early diagnosis and monitoring of diseases at the molecular level.