949143-87-7Relevant articles and documents
Synthesis and calming activity of 6H-2-amino-4-aryl-6- (4-β-D- allopyranosyloxyphenyl)-1,3-thiazine
Fu, Li,Ye, Ding,Li, Ying,Yin, Shufan
scheme or table, p. 169 - 172 (2010/10/20)
E-(4-β-D-Allopyranosyloxyphenyl)-1-(4-substituted phenyl)propenone derivatives (1a-g) have been synthesized by the Claisen-Schmidt condensation of helicid with 4-substituted acetophenone using 10% NaOH aqueous solution as a catalyst. 6H-2-Amino-4-aryl-6-(4-β-D-allopyranosyloxyphenyl)-1,3-thiazine (2a-g) were synthesized by the 1,4-Michael reaction of 1a-g with thiourea. The structures of all the new products were established by 1H NMR, IR, and MS spectroscopy. Compound 2b (200 mg.kg-1) showed better sedative-hypnotic activity, so further modification of helicid should be worthwhile.