96134-79-1

Basic information

• Product Name: 3-HYDRAZINOCARBONYL-N,N-DIMETHYL-BENZENESULFONAMIDE
• Synonyms: 3-(hydrazinecarbonyl)-N,N-dimethylbenzenesulfonamide
• CAS NO: 96134-79-1
• Molecular Formula: C₉H₁₃N₃O₃S
• Molecular Weight: 243.28626
• Mol File: 96134-79-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.333g/cm³
• Refractive Index: 1.579
• CAS DataBase Reference: 3-HYDRAZINOCARBONYL-N,N-DIMETHYL-BENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-HYDRAZINOCARBONYL-N,N-DIMETHYL-BENZENESULFONAMIDE(96134-79-1)
• EPA Substance Registry System: 3-HYDRAZINOCARBONYL-N,N-DIMETHYL-BENZENESULFONAMIDE(96134-79-1)

Safety Data

• Hazardous Substances Data: 96134-79-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H13N3O3S/c1-12(2)16(14,15)8-5-3-4-7(6-8)9(13)11-10/h3-6H,10H2,1-2H3,(H,11,13)

Upstream product

• 823833-29-0 methyl 3-(N,N-dimethylsulfamoyl)benzoate 
• 7326-73-0 3-<(Dimethylamino)sulfonyl>benzoic Acid 
• 4025-64-3 3-Carboxybenzenesulfonyl chloride 
• 83112-39-4 3-<(Dimethylamino)sulfonyl>benzoic Acid Ethyl Ester 

Downstream Products

• 96134-50-8 3-(5-Methyl-1,3,4-oxadiazol-2-yl)-N,N-dimethylbenzenesulfonamide 
• 1423715-15-4 (E)-3-(2-(1-(5-chloro-2-hydroxyphenyl)ethylidene)hydrazinecarbonyl)-N,N-dimethylbenzenesulfonamide 
• 1571911-55-1 N'-(7-amino-5H-pyrrolo[3,4-b]pyrazin-5-ylidene)-3-[(dimethylamino)sulfonyl]benzohydrazide 
• 96134-52-0 N,N-Dimethyl-3-(5-phenyl-[1,3,4]oxadiazol-2-yl)-benzenesulfonamide 
• 96134-49-5 3-(1,3,4-Oxadiazol-2-yl)-N,N-dimethylbenzenesulfonamide 

Relevant articles and documents

Synthesis and biological evaluation of novel (E)-N′-(2,3-dihydro-1H-inden-1-ylidene) benzohydrazides as potent LSD1 inhibitors

Lysine specific demethylase 1 (LSD1) plays an important role in regulating histone lysine methylation at residues K4 and K9 on histone H3 and is recognized as an attractive therapeutic target in multiple malignancies. In this study, a series of novel (E)-N′-(2,3-dihydro-1H-inden-1-ylidene) benzohydrazides were synthesized and biologically evaluated for their potential LSD1 inhibitory effect. Among them, compounds 5a and 5n showed the most potent LSD1 inhibitory activity with IC50values of 1.4 and 1.7?nM, respectively, which were about 10 times more potent compared with (E)-N-(1-(5-chloro-2-hydroxyphenyl) ethylidene)-3-(morpholinosulf-only) benzohydrazide (J. Med. Chem. 2013, 56, 9496–9508; as reference compound). Compounds 5a and 5n also exhibited marked anti-proliferation activities against cancer cell lines that highly expressed LSD1. These results suggest that these optimized compounds might be served as promising LSD1 inhibitors against cancer, which merit further study.

SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE) BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIITORS

In one aspect, the invention relates to substituted (E)-N'-(1- phenylethylidene)benzohydrazide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of lysine-specific histone demethylase, including LSD1; synthetic methods fo