96206-92-7 Usage
Description
MPEP, also known as 2-Methyl-6-(2-phenylethynyl)pyridine, is a potent, subtype-selective mGluR5 antagonist. It is a chemical compound that has been found to modulate the activity of the metabotropic glutamate receptor 5 (mGluR5), which plays a crucial role in various neurological processes.
Used in Pharmaceutical Industry:
MPEP is used as a research tool for studying the role of mGluR5 in neurological disorders and as a potential therapeutic agent for the treatment of such conditions.
Used in Alzheimer's Disease Research:
MPEP is used as a pharmacological agent to induce pathophysiological mGluR5 signaling in Alzheimer's disease model mice in a sex-selective manner. This helps researchers understand the role of mGluR5 in the progression of Alzheimer's disease and develop targeted therapies.
Used in Neurological Disorders Research:
MPEP is used as a potent, subtype-selective mGluR5 antagonist for investigating the role of mGluR5 in various neurological disorders, including Fragile X syndrome, schizophrenia, and drug addiction. Its ability to modulate mGluR5 activity makes it a valuable tool in the development of novel therapeutic strategies for these conditions.
Biological Activity
Potent and highly selective non-competitive antagonist at the mGlu 5 receptor subtype (IC 50 = 36 nM) and a positive allosteric modulator at mGlu 4 receptors. Centrally active following systemic administration in vivo . Reverses mechanical hyperalgesia in the inflamed rat hind paw. Also available as part of the Group I mGlu Receptor Tocriset? .
references
[1] gasparini f, lingenh?hl k, stoehr n, et al. 2-methyl-6-(phenylethynyl)-pyridine (mpep), a potent, selective and systemically active mglu5 receptor antagonist. neuropharmacology, 1999, 38(10): 1493-1503.[2] tatarczyńska e, k?odzińska a, chojnacka-wójcik e, et al. potential anxiolytic-and antidepressant-like effects of mpep, a potent, selective and systemically active mglu5 receptor antagonist. british journal of pharmacology, 2001, 132(7): 1423-1430.
Check Digit Verification of cas no
The CAS Registry Mumber 96206-92-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,6,2,0 and 6 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 96206-92:
(7*9)+(6*6)+(5*2)+(4*0)+(3*6)+(2*9)+(1*2)=147
147 % 10 = 7
So 96206-92-7 is a valid CAS Registry Number.
InChI:InChI=1/C14H11N.ClH/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13;/h2-9H,1H3;1H
96206-92-7Relevant articles and documents
Mononuclear and dinuclear heteroleptic Cu(I) complexes based on pyridyl-triazole and DPEPhos with long-lived excited-state lifetimes
Bizzarri, Claudia,Arndt, Andreas P.,Kohaut, Stephan,Fink, Karin,Nieger, Martin
, p. 140 - 149 (2018/07/25)
A mononuclear and two dinuclear heteroleptic Cu(I) complexes have been successfully prepared, using the chelating bis [(2-diphenylphosphino)phenyl] ether (DPEPhos) and pyrid-2′-yl-1H-1,2,3-triazole as N?N chelating ligands. They show good luminescence in solution at room temperature with long-lived excited states. Furthermore, bimolecular quenching experiments of these new complexes with the catalyst Ni(cyclam)Cl2 encourage the use of such compounds as photosensitizers for the photoreduction of carbon dioxide.
Palladium-catalyzed deacetonative coupling of aryl propargylic alcohols with aryl chlorides in water
Chang, Feng,Liu, Yanping
supporting information, p. 961 - 967 (2017/05/04)
A highly efficient and green process for palladium-catalyzed deacetonative coupling of aryl propargylic alcohols with aryl chlorides has been developed. The reaction occurs smoothly in neat water with 2 mol% PdCl2 as catalyst, and various synthetically useful functional groups, including ether, aldehyde, ketone, and heterocyclics, are well tolerated. Moreover, the reaction could proceed through a consecutive Sonogashira/deacetonative process using 2-methyl-3-butyn-2-ol and aryl chlorides as coupling partners, affording the symmetric alkynes in good yields.
Simultaneous rapid reaction workup and catalyst recovery
Lu, Zhichao,Hetman, Zofia,Hammond, Gerald B.,Xu, Bo
supporting information, p. 5769 - 5772 (2016/11/06)
By combining reaction work-up and catalyst recovery into a simple filtration procedure we have developed a substantially faster technique for organic synthesis. Our protocol eliminates the time-consuming conventional liquid-liquid extraction and is capable of parallelization and automation. Additionally, it requires only minimal amounts of solvent.
