97699-67-7Relevant articles and documents
ABSORBABLE BRANCHED POLYESTERS AND POLYURETHANES
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Paragraph 0210-0212, (2014/05/25)
The present invention relates to the discovery of a new class of hydrolysable isocyanates, hydrolysable branched polyols and branched absorbable polyesters and polyurethanes prepared therefrom. The resultant absorbable polymers are useful for drug delivery, stents, highly porous foam, reticulated foam, tissue engineering, tissue adhesives, adhesion prevention, bone wax formulations, medical device coatings, surface modifying agents and other implantable medical devices. In addition, these absorbable polymers can have a controlled hydrolytic degradation profile.
CHEMICAL COMPOUNDS CONTAINING TOCOPHEROL AND AT LEAST ONE ADDITIONAL PHARMACEUTICAL ACTIVE SUBSTANCE
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Page/Page column 26-29, (2010/02/10)
The invention relates to chemical compounds in the form of racemates, enantiomers and/or diastereomers of general formula (I), wherein R represents the non-modified part of a variable pharmaceutical active substance molecule, B represents a spacer and Toc and corresponds to formula (II), R′, R′′ and R′′′ are H or methyl for tocopherol and A is C=X, SOm, X and/or CH2. X is O, S or NR1 (n = 1) and/or S or NR1 (n = 0) and B is a group X-R 2 y, wherein Y is C=X, SOm or C (XR 3 ) R4, and n is 0 - 6, preferably 0,1, 2 or 3 and m represents 1 or 2. R1 represents H, C1 - C10 -alkyl, preferably C1 - C6-alkyl and/or aryl, Het or an aryl radical and/or a Het radical connected via a C1 - C6 spacer, preferably C1 - C3 and R2 is selected from the group containing alkene, arylene and/or Het spacer and combinations thereof and can be combined directly with each other or via the A radical and/or via the group XO-A-Xp, wherein o and p can be equal or different and are 0, 1 or 2, and R3 and R4 represent H, C1 - C10 alkyl, preferably C1-C6-alkyl and/or aryl, Het or an aryl radical and/or a Het radical bound by means of a C1 - C6, preferably C1 - C3 spacer.
