98215-47-5

Basic information

• Product Name: 2-Thiophenecarboxamide, 5-chloro-N-[2-(3,4-dimethoxyphenyl)ethyl]-
• CAS NO: 98215-47-5
• Molecular Formula: C15H16ClNO3S
• Molecular Weight: 325.816
• Mol File: 98215-47-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Thiophenecarboxamide, 5-chloro-N-[2-(3,4-dimethoxyphenyl)ethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiophenecarboxamide, 5-chloro-N-[2-(3,4-dimethoxyphenyl)ethyl]-(98215-47-5)
• EPA Substance Registry System: 2-Thiophenecarboxamide, 5-chloro-N-[2-(3,4-dimethoxyphenyl)ethyl]-(98215-47-5)

Safety Data

• Hazardous Substances Data: 98215-47-5(Hazardous Substances Data)

Upstream product

• 42518-98-9 5-chlorothiophene-2-carbonyl chloride 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 

Relevant articles and documents

Dehalogenation of 1-Halogenothienyl-di- and -tetra-hydroisoquinolines by Sodium Methoxide in Dimethyl Sulphoxide

On treatment with sodium methoxide-dimethyl sulphoxide (NaOMe-DMSO) 1-(5-halogeno-2-thienyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolines suffer loss of halogen and are converted into the related 1-hydroxytetrahydroisoquinolines.The reaction fails with comparable 1-bromophenyl- and 1-(halogeno-3-thienyl)tetrahydroisoquinolines.A similar transformation takes place with (5-halogeno-2-thienyl)phenylmethoxymethanes, leading to the dimethyl acetal of the 5-dehalogenated-2-thienyl phenyl ketone. α-Halogenated-2 and 3-thienyl-3,4-dihydroisoquinolines undergo dehalogenation-aromatisation with NaOMe-DMSO.Mechanisms for these conversions are proposed.