98367-45-4

Basic information

• Product Name: Protected Imipenem
• Synonyms: protected imipenem;(5R,6S)-4-Nitrobenzyl-3-[[2-[[[[[(4-nitrophenyl)methoxy]carbonyl]amino]methylene]amino]ethyl]thio]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3,2,0]hept-2-ene-2-carboxylate;BIS PROTECTED IMIPENEM;(4R,5S,6S)-4-NITROBENZYL-3-[[(3S,5S)-5-[(DIMETHYLAMINO)CARBONYL]-1-[[(4-NITROBENZYL)OXY] CARBONYL]-3-PYRROLIDINYL]THIO]-6-[(1R)-1-HYDROXYETHYL]-4-METHYL-7-OXO-1-AZABICYCLO[3,2,0] HEPT-2-ENE-2-CARBOXYLATE;[5R-α,6α(R*)]]- 6-(1-hydroxyethyl)-3-[[2-[[[[[(4-nitrophenyl)Methoxy]carbonyl]aMino]Methylene]aMino]
• CAS NO: 98367-45-4
• Molecular Formula: C27H27N5O10S
• Molecular Weight: 613.6
• Mol File: 98367-45-4.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 791.6°C at 760 mmHg
• Flash Point: 432.5°C
• Appearance: /
• Density: 1.55g/cm³
• Vapor Pressure: 2.06E-26mmHg at 25°C
• Refractive Index: 1.711
• CAS DataBase Reference: Protected Imipenem(CAS DataBase Reference)
• NIST Chemistry Reference: Protected Imipenem(98367-45-4)
• EPA Substance Registry System: Protected Imipenem(98367-45-4)

Safety Data

• Hazardous Substances Data: 98367-45-4(Hazardous Substances Data)

Usage

General Description

Protected Imipenem is a broad-spectrum beta-lactam antibiotic derived from Streptomyces cattleya. It is used in the treatment of severe or high-risk bacterial infections. The compound is administered in combination with cilastatin, which inhibits the renal metabolism of imipenem, thereby maintaining therapeutic drug levels in the serum and urine. It works by binding to the penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall, thereby inhibiting bacterial cell wall synthesis. Side effects can include diarrhea, nausea, vomiting, rash, seizures, and allergic reactions. Resistance to Imipenem can develop in some bacterial strains.

InChI:InChI=1/C24H23N5O8S/c1-14(30)21-19-12-20(38-11-10-25-13-26-15-2-4-16(5-3-15)28(33)34)22(27(19)23(21)31)24(32)37-18-8-6-17(7-9-18)29(35)36/h2-9,13-14,19,21,30H,10-12H2,1H3,(H,25,26)/t14?,19-,21-/m1/s1