99380-81-1 Usage
Description
2-PHENYLTHIAZOLIDINE-4-CARBOXYLIC ACID METHYL ESTER, also known as methyl 2-phenylthiazolidine-4-carboxylate, is a chemical compound characterized by a thiazolidine ring with a phenyl group attached. It serves as a versatile building block in organic synthesis, particularly for the development of pharmaceuticals and agrochemicals. 2-PHENYLTHIAZOLIDINE-4-CARBOXYLIC ACID METHYL ESTER has demonstrated potential as an anti-inflammatory and anti-cancer agent, with its ability to inhibit cancer cell growth and reduce inflammation. Additionally, it is utilized as a chiral auxiliary in asymmetric synthesis to produce enantiomerically pure compounds, highlighting its significance in the fields of medicine and chemistry.
Uses
Used in Pharmaceutical Industry:
2-PHENYLTHIAZOLIDINE-4-CARBOXYLIC ACID METHYL ESTER is used as a building block for the synthesis of pharmaceuticals due to its versatile chemical structure and potential therapeutic properties.
Used in Agrochemical Industry:
2-PHENYLTHIAZOLIDINE-4-CARBOXYLIC ACID METHYL ESTER is used as a building block for the development of agrochemicals, contributing to the creation of effective and targeted pest control solutions.
Used in Anti-inflammatory Applications:
2-PHENYLTHIAZOLIDINE-4-CARBOXYLIC ACID METHYL ESTER is used as an anti-inflammatory agent for its ability to reduce inflammation, offering potential benefits in the treatment of various inflammatory conditions.
Used in Anti-cancer Applications:
2-PHENYLTHIAZOLIDINE-4-CARBOXYLIC ACID METHYL ESTER is used as an anti-cancer agent, exhibiting the capacity to inhibit the growth of cancer cells, making it a promising candidate for cancer therapy.
Used in Asymmetric Synthesis:
2-PHENYLTHIAZOLIDINE-4-CARBOXYLIC ACID METHYL ESTER is used as a chiral auxiliary in asymmetric synthesis to create enantiomerically pure compounds, which is crucial for the development of highly selective and potent pharmaceuticals.
Check Digit Verification of cas no
The CAS Registry Mumber 99380-81-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,9,3,8 and 0 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 99380-81:
(7*9)+(6*9)+(5*3)+(4*8)+(3*0)+(2*8)+(1*1)=181
181 % 10 = 1
So 99380-81-1 is a valid CAS Registry Number.
99380-81-1Relevant articles and documents
THIAZOLIDINONE AMIDES, THIAZOLIDINE CARBOXYLIC ACID AMIDES, AND SERINE AMIDES, INCLUDING POLYAMINE CONJUGATES THEREOF, AS SELECTIVE ANTI-CANCER AGENTS
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Page/Page column 4; sheet 2, (2008/12/04)
Substituted thiazolidinone carboxylic acid amides and substituted thiazolidine carboxylic acid amides having a structure where the various substituent groups are as defined in the specification. Methods of making these compounds, pharmaceutical compositions containing the compounds, and their use, particularly for treating or preventing cancer, are also disclosed.
Discovery of 2-arylthiazolidine-4-carboxylic acid amides as a new class of cytotoxic agents for prostate cancer
Gududuru, Veeresa,Hurh, Eunju,Dalton, James T.,Miller, Duane D.
, p. 2584 - 2588 (2007/10/03)
To improve the selectivity and antiproliferative activity of previously reported serine amide phosphates (SAPs), we designed a new series of 4-thiazolidinone amides, in which the 4-thiazolidinone moiety was introduced as a phosphate mimic. However, these 4-thiazolidinone derivatives demonstrated less cytotoxicity in prostate cancer cells despite improved selectivity over RH7777 cells. To further optimize the thiazolidinone analogues in terms of cytotoxicity and selectivity, we made closely related structural modifications, which led us to the discovery of a new class of 2-arylthiazolidine-4-carboxylic acid amides. These compounds were potent cytotoxic agents with IC50 values in the low micromolar concentration range and demonstrated enhanced selectivity in receptor-negative cells compared to SAPs and 4-thiazolidinone amides.
