99429-99-9

Basic information

• Product Name: 4-methylphenyl (2E)-3-phenylprop-2-enoate
• Synonyms: 4-methylphenyl (2E)-3-phenylprop-2-enoate
• CAS NO: 99429-99-9
• Molecular Weight: 238.286
• Mol File: 99429-99-9.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: 4-methylphenyl (2E)-3-phenylprop-2-enoate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methylphenyl (2E)-3-phenylprop-2-enoate(99429-99-9)
• EPA Substance Registry System: 4-methylphenyl (2E)-3-phenylprop-2-enoate(99429-99-9)

Safety Data

• Hazardous Substances Data: 99429-99-9(Hazardous Substances Data)

Upstream product

• 106-44-5 p-cresol 
• 102-92-1 cinnamoyl chloride 
• 15088-77-4 cinnamic dithioperoxyanhydride 
• 112404-04-3 O-methyl cinnamohydroxamate 
• 102-92-1 Cinnamoyl chloride 
• 140-10-3 (E)-3-phenylacrylic acid 
• 14371-10-9 (E)-3-phenylpropenal 
• 5720-05-8 4-methylphenylboronic acid 
• 775-12-2 diphenylsilane 
• 201230-82-2 carbon monoxide 
• 536-74-3 phenylacetylene 
• 14643-62-0 tris(p-methylphenyl) borate 
• 21947-71-7 cinnamic anhydride 
• 18736-43-1 4-nitro-phenyl cinnamate 

Downstream Products

• 124-38-9 carbon dioxide 
• 4714-21-0 4-methylstilbene 
• 40546-94-9 6-methyl-4-phenyl-3,4-dihydrocoumarin 
• 1775-98-0 2'-hydroxy-5'-methylchalcone 
• 109089-77-2 3-(2-methoxy-5-methyl-phenyl)-3-phenyl-propionic acid 
• 16299-22-2 6-methyl-4-phenylchromen-2-one 
• 3489-11-0 6-methylflavanone 
• 1775-98-0 (E)-1-(2-hydroxy-5-methylphenyl)-3-phenylprop-2-en-1-one 
• 4714-21-0 E-1-methyl-4-styryl-benzene 

Relevant articles and documents

The design and synthesis of transient receptor potential vanilloid 3 inhibitors with novel skeleton

Transient receptor potential vanilloid 3 (TRPV3) channel as a member of thermo TRPV subfamily is primarily expressed in the keratinocytes of the skin and sensory neurons, and plays critical roles in various physiological and pathological processes such as

Preparation method for synthesis of phenolic ester through thiocarboxylic acid mediated visible light catalyzed phenol acylation reaction

The invention discloses a preparation method for synthesis of phenolic ester through a thiocarboxylic acid mediated visible light catalyzed phenol acylation reaction. Thiocarboxylic acid compounds andphenol compounds are subjected to a site specific reaction under certain conditions to produce phenolic ester compounds, wherein the certain conditions are as follows: under the conditions of normaltemperature, normal pressure and visible light, K2CO3 is used as an alkaline catalyst, terpyridyl ruthenium dichloride hexahydrate is used as a photosensitizer and acetonitrile is used as a reaction solvent. Synthesis of phenolic ester under catalysis of visible light is realized, thiocarboxylic acid is used as an acylation reagent, and the site specific phenol esterification reaction is realizedefficiently under mild conditions of normal temperature, normal pressure and visible light. The method has mild reaction conditions, large substrate functional group tolerance, high applicability andhigh yield, and an efficient, reliable and economical preparation method is provided for synthesis of phenolic ester.

Diacyl Disulfide: A Reagent for Chemoselective Acylation of Phenols Enabled by 4-(N,N-Dimethylamino)pyridine Catalysis

A general and excellent acylation reagent, diacyl disulfide, was uncovered for efficient ester formation enabled by DMAP (4-(N,N-dimethylamino)pyridine) catalysis. This protocol offered a promising synthetic platform on site-selective acylation of phenolic and primary aliphatic hydroxyl groups, which greatly expanded the realm of protecting group chemistry. The importance of the reagent was also reflected by its excellent moisture tolerance, high efficiency, and potential in synthetic chemistry and biologically meaningful natural product modification.