99747-74-7 Usage
Description
1-NAPHTHYL TRIFLATE, with the chemical formula C11H7F3O3S, is a triflate ester derivative of 1-naphthol. It is a reagent in organic synthesis, known for its mild electrophilic properties and ability to transfer the naphthyl group to nucleophiles. This makes it a valuable tool in the preparation of various functionalized naphthalene derivatives.
Uses
Used in Organic Synthesis:
1-NAPHTHYL TRIFLATE is used as a reagent for facilitating the transfer of the naphthyl group to nucleophiles in various reactions, such as cross-coupling reactions and nucleophilic aromatic substitution.
Used in Pharmaceutical Industry:
1-NAPHTHYL TRIFLATE is used as a reagent for the preparation of functionalized naphthalene derivatives, which are valuable in the development of pharmaceutical compounds.
Used in Agrochemical Industry:
1-NAPHTHYL TRIFLATE is used as a reagent for the synthesis of naphthalene-based agrochemicals, contributing to the development of effective crop protection agents.
Used in Materials Science:
1-NAPHTHYL TRIFLATE is used as a reagent for the synthesis of naphthalene-based materials, which can be utilized in various applications within the materials science field.
Check Digit Verification of cas no
The CAS Registry Mumber 99747-74-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,9,7,4 and 7 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 99747-74:
(7*9)+(6*9)+(5*7)+(4*4)+(3*7)+(2*7)+(1*4)=207
207 % 10 = 7
So 99747-74-7 is a valid CAS Registry Number.
InChI:InChI=1/C11H7F3O3S/c12-11(13,14)18(15,16)17-10-7-3-5-8-4-1-2-6-9(8)10/h1-7H
99747-74-7Relevant articles and documents
Palladium-Catalyzed Reductive Carbonylation of (Hetero) Aryl Halides and Triflates Using Cobalt Carbonyl as CO Source
Dogga, Bhushanarao,Joseph, Jayan T.,Kumar, C. S. Ananda
supporting information, p. 309 - 313 (2020/12/23)
An efficient protocol for the reductive carbonylation of (hetero) aryl halides and triflates under CO gas-free conditions using Pd/Co2(CO)8 and triethylsilane has been developed. The mild reaction conditions, enhanced chemoselectivity and, easy access to heterocyclic and vinyl carboxaldehydes highlights its importance in organic synthesis.
Pd-Catalyzed Intermolecular Transthiolation of Ar-OTf Using Methyl 3-(Methylthio) Propanoate as a Thiol Surrogate
Pan, Dandan,Xu, Shasha,Tian, Qingqiang,Li, Yahui
supporting information, p. 4616 - 4619 (2021/09/10)
A method for the odorless synthesis of unsymmetrical sulfides via Csp2?O and Csp3?S bond activation is presented. Using methyl 3-(methylthio) propanoate as a MeSH surrogate, a series of substituted aryl methyl sulfides have been obtained in moderate to good yields. This catalytic protocol can also tolerate methyl 3-(methylthio)propionate derivatives to afford the corresponding aryl sulfides.
KRAS G12C INHIBITORS
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Paragraph 0292, (2020/03/23)
The present invention relates to compounds that, inhibit KRas G12C, In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
