99846-93-2 Usage
Description
2',5'-DICHLOROPROPIOPHENONE, with the molecular formula C9H7Cl2O, is a white crystalline solid that is soluble in organic solvents but insoluble in water. It is a chemical compound often utilized as an intermediate in the synthesis of various products, including pharmaceuticals, agrochemicals, dyes, and pigments. Additionally, it exhibits antimicrobial properties, which contribute to its applications in industrial and medical fields. However, due to its toxic and potentially hazardous nature, careful handling is required to mitigate health and environmental risks.
Uses
Used in Pharmaceutical Industry:
2',5'-DICHLOROPROPIOPHENONE is used as a chemical intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and medicines.
Used in Agrochemical Industry:
In the agrochemical sector, 2',5'-DICHLOROPROPIOPHENONE serves as an intermediate in the production of agrochemicals, aiding in the creation of substances that protect crops and enhance agricultural productivity.
Used in Dye and Pigment Production:
2',5'-DICHLOROPROPIOPHENONE is utilized as a chemical intermediate in the manufacturing process of dyes and pigments, playing a role in the coloration of various materials and products.
Used in Industrial and Medical Applications:
Due to its antimicrobial properties, 2',5'-DICHLOROPROPIOPHENONE is employed in certain industrial and medical applications, where it helps to control microbial growth and maintain cleanliness and hygiene.
Check Digit Verification of cas no
The CAS Registry Mumber 99846-93-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,9,8,4 and 6 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 99846-93:
(7*9)+(6*9)+(5*8)+(4*4)+(3*6)+(2*9)+(1*3)=212
212 % 10 = 2
So 99846-93-2 is a valid CAS Registry Number.
99846-93-2Relevant articles and documents
Discovery of N-(4-aryl-5-aryloxy-thiazol-2-yl)-amides as potent RORγt inverse agonists
Wang, Yonghui,Yang, Ting,Liu, Qian,Ma, Yingli,Yang, Liuqing,Zhou, Ling,Xiang, Zhijun,Cheng, Ziqiang,Lu, Sijie,Orband-Miller, Lisa A.,Zhang, Wei,Wu, Qianqian,Zhang, Kathleen,Li, Yi,Xiang, Jia-Ning,Elliott, John D.,Leung, Stewart,Ren, Feng,Lin, Xichen
, p. 5293 - 5302 (2015/11/10)
A novel series of N-(4-aryl-5-aryloxy-thiazol-2-yl)-amides as RORγt inverse agonists was discovered. Binding mode analysis of a RORγt partial agonist (2c) revealed by co-crystal structure in RORγt LBD suggests that the inverse agonists do not directly interfere with the interaction between H12 and the RORγt LBD. Detailed SAR exploration led to identification of potent RORγt inverse agonists such as 3m with a pIC50 of 8.0. Selected compounds in the series showed reasonable activity in Th17 cell differentiation assay as well as low intrinsic clearance in mouse liver microsomes.
