Spectrophotometric determination of OBIDOXIME CHLORIDE (cas 114-90-9) as its Pd(II) complex in water and injections☆
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Add time:08/22/2019 Source:sciencedirect.com
It has been established that OBIDOXIME CHLORIDE (cas 114-90-9) reacts with palladium(II) chloride in the pH range 3.9–8.0 and forms a yellow water-soluble (1:1) complex with maximum absorbance at 355 nm. By applying the methods of Sommer, Nash and Job involving non-equimolar solutions the conditional stability constant of the complex, at the optimum pH of 6.3 and an ionic strength μ = 0.55 M, is found to be 105.3. The molar absorptivity at 355 nm is 3.16 × 104 l mol−1 cm−1 at pH 6.3. Beer's law is obeyed up to 20 μmol l−1 obidoxime chloride concentration. The detection limit of the method is 0.36 μg ml−1. The relative standard deviation (n = 10) varies over the range 1.10–2.66%. The proposed method was found to be suitable for the accurate and sensitive analysis of obidoxime chloride in water and injection solutions.
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