Sinomenine (cas 115-53-7) enhances microglia M2 polarization and attenuates inflammatory injury in intracerebral hemorrhage
-
Add time:08/30/2019 Source:sciencedirect.com
Microglia polarization plays a vital role in brain inflammatory injury following intracerebral hemorrhage (ICH). Previous studies have shown that Sinomenine (cas 115-53-7) possesses potential immunoregulatory capabilities. However, microglia polarization's exact mechanisms in ICH remain uncertain. Therefore, we examined the role of sinomenine on microglia polarization and brain inflammation following ICH. For the experiment, autologous blood models were constructed in C57/BL6 mice. Markers of classically activated (M1) and alternatively activated (M2) microglia were detected by real-time polymerase chain reaction, immunofluorescence, and flow cytometry. Microglial toxicity was assessed using MTT and FACS assays. In addition, the neurological deficit and cerebral water content of ICH mice were also observed. Sinomenine attenuated M1 markers while promoting M2 markers of microglia. Sinomenine also protected hippocampal neurons from indirect toxicity mediated by ICH-treated microglia. Additionally, administration of sinomenine inhibited matrix metalloproteinase (MMP) 3/9 expression, cerebral water content, and neurological deficit. Therefore, sinomenine protected brain function following ICH, perhaps via M2 microglia phenotype induction and MMP 3/9 inhibition. This result suggests that sinomenine is a promising therapeutical strategy in ICH.
We also recommend Trading Suppliers and Manufacturers of Sinomenine (cas 115-53-7). Pls Click Website Link as below: cas 115-53-7 suppliers
Prev:Sinomenine (cas 115-53-7) contributes to the inhibition of the inflammatory response and the improvement of osteoarthritis in mouse-cartilage cells by acting on the Nrf2/HO-1 and NF-κB signaling pathways
Next:Controlling heat release of crystallization from supercooling state of a solid-solid PCM, 2-Amino-2-methyl-1,3-propanediol (cas 115-69-5)) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Sinomenine (cas 115-53-7) contributes to the inhibition of the inflammatory response and the improvement of osteoarthritis in mouse-cartilage cells by acting on the Nrf2/HO-1 and NF-κB signaling pathways08/29/2019
- In situ hexagonal liquid crystal for intra-articular delivery of Sinomenine (cas 115-53-7) hydrochloride08/28/2019
- Protective effects of Sinomenine (cas 115-53-7) against LPS-induced inflammation in piglets08/27/2019
- Co-administration with simvastatin or lovastatin alters the pharmacokinetic profile of Sinomenine (cas 115-53-7) in rats through cytochrome P450-mediated pathways08/26/2019
- Simultaneous determination of alkaloids dicentrine and Sinomenine (cas 115-53-7) in Stephania epigeae by 1H NMR spectroscopy08/25/2019
- Pharmacokinetics of Sinomenine (cas 115-53-7) hydrochloride cubic liquid crystal injection based on microdialysis technology08/24/2019
- Sinomenine (cas 115-53-7) inhibits proliferation, migration, invasion and promotes apoptosis of prostate cancer cells by regulation of miR-23a08/23/2019
- Research articlePossible involvement of the μ opioid receptor in the antinociception induced by Sinomenine (cas 115-53-7) on formalin-induced nociceptive behavior in mice08/22/2019