Administration of HUPERZINE (cas 116-28-9) A exerts antidepressant-like activity in a rat model of post-stroke depression
-
Add time:08/31/2019 Source:sciencedirect.com
Post-stroke depression (PSD) is the most common mood disorder following a stroke, and is also the main factor limiting recovery and rehabilitation in stroke patients. The present study was aimed to investigate whether HUPERZINE (cas 116-28-9) A (HupA) has antidepressant-like activity in a rat model of PSD, which was developed by middle cerebral artery occlusion followed by an 18-day chronic unpredictable mild stress in conjunction with isolation rearing. The sucrose preference and forced swim tests were used to assess depression-like behavior. Neurological and cognitive functions following ischemia were evaluated by neurological evaluation, the beam-walking test, the forelimb grip force test, and the water maze test. Levels of norepinephrine (NE), dopamine (DA), and 5-hydroxytryptamine (5-HT) in the hippocampus and prefrontal cortex were assayed by high performance liquid chromatography. Western blot analysis was used to evaluate hippocampal expression of the 5-hydroxytryptamine 1A receptor (5-HT1AR), cAMP response element binding (CREB), phosphorylated CREB (p-CREB) and brain-derived neurotrophic factor (BDNF). The results showed that treatment with HupA for 4 weeks ameliorated behavioral abnormalities and the impairment of neurological and cognitive functions in PSD rats. This was accompanied by the upregulated hippocampal expression of 5-HT1AR, p-CREB and BDNF, and increased levels of NE, DA, and 5-HT in the hippocampus and prefrontal cortex. These findings suggest that HupA has antidepressant-like effect and can improve neurological and cognitive functions in PSD rats, which suggest its therapeutic potential for depression after stroke.
We also recommend Trading Suppliers and Manufacturers of HUPERZINE (cas 116-28-9). Pls Click Website Link as below: cas 116-28-9 suppliers
Prev:Simultaneously preparative purification of HUPERZINE (cas 116-28-9) A and HUPERZINE (cas 116-28-9) B from Huperzia serrata by macroporous resin and preparative high performance liquid chromatography
Next:Nephrotoxic effect of Tetradifon (cas 116-29-0) in rats: A biochemical and histomorphometric study) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Simultaneously preparative purification of HUPERZINE (cas 116-28-9) A and HUPERZINE (cas 116-28-9) B from Huperzia serrata by macroporous resin and preparative high performance liquid chromatography08/30/2019
- Structural analogs of HUPERZINE (cas 116-28-9) A improve survival in guinea pigs exposed to soman08/29/2019
- A combination of [+] and [−]-HUPERZINE (cas 116-28-9) A improves protection against soman toxicity compared to [+]-HUPERZINE (cas 116-28-9) A in guinea pigs08/28/2019
- Variations of HUPERZINE (cas 116-28-9) A content in Lycopodiaceae species from tropics08/27/2019
- Microbial transformation of (−)-HUPERZINE (cas 116-28-9) A08/26/2019
- Abcb1a but not Abcg2 played a predominant role in limiting the brain distribution of HUPERZINE (cas 116-28-9) A in mice08/25/2019
- ABAD/17β-HSD10 reduction contributes to the protective mechanism of HUPERZINE (cas 116-28-9) a on the cerebral mitochondrial function in APP/PS1 mice08/24/2019
- Original ArticleHUPERZINE (cas 116-28-9)-A response to cognitive impairment and task switching deficits in patients with Alzheimer's disease08/23/2019
- HUPERZINE (cas 116-28-9) a loaded multiparticulate disintegrating tablet: Drug release mechanism of ethyl cellulose microparticles and pharmacokinetic study08/22/2019