- Synthesizing method of Sitagliptin
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The invention provides a synthesizing method of the compound, namely Sitagliptin, described in the formula (1). The compound described in the formula (2) as a starting material is subjected to the following series of reactions, and finally the compound, namely Sitagliptin, described in the formula (1) is prepared. Compared with the prior art in which a lot of Sitagliptin synthesizing steps exist and the synthesizing technology is complex, the synthesizing method is simple and easy to implement, low in cost, high in yield, good in product quality and suitable for large-scale industrial production.
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Paragraph 0013; 0014
(2017/10/28)
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- INTERMEDIATES OF SITAGLIPTIN AND PREPARATION PROCESS THEREOF
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Disclosed are intermediates of Sitagliptin, a preparation process thereof, and a process for synthesizing Sitagliptin using these intermediates. Sitagliptin is synthesized by using chiral amino compounds as a raw material, without having to build a chiral center with a chiral asymmetric catalytic hydrogenation, and high-pressure hydrogenation is avoided.
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Paragraph 0262-0263
(2013/11/05)
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- INTERMEDIATES OF SITAGLIPTIN AND PREPARATION PROCESS THEREOF
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Disclosed are intermediates of Sitagliptin, a preparation process thereof, and a process for synthesizing Sitagliptin using these intermediates. Sitagliptin is synthesized by using chiral amino compounds as a raw material, without having to build a chiral center with a chiral asymmetric catalytic hydrogenation, and high-pressure hydrogenation is avoided.
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