1306610-49-0

Basic information

• Product Name: C₂₃H₂₁F₆N₅O
• Synonyms: C₂₃H₂₁F₆N₅O
• CAS NO: 1306610-49-0
• Molecular Weight: 497.443
• Mol File: 1306610-49-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₂₃H₂₁F₆N₅O(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₂₁F₆N₅O(1306610-49-0)
• EPA Substance Registry System: C₂₃H₂₁F₆N₅O(1306610-49-0)

Safety Data

• Hazardous Substances Data: 1306610-49-0(Hazardous Substances Data)

Upstream product

• 1253056-18-6 C₁₆H₁₂F₆N₄O 
• 100-46-9 benzylamine 
• 1380569-10-7 C₁₇H₁₆F₃NO₂ 
• 762240-92-6 3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride 
• 1380243-43-5 C₁₇H₁₆F₃NO₂ 
• 1380243-46-8 C₁₇H₁₄F₃NO₃ 

Downstream Products

• 654671-78-0 (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine phosphate 
• 486460-32-6 sitagliptin 

Relevant articles and documents

Synthesizing method of Sitagliptin

The invention provides a synthesizing method of the compound, namely Sitagliptin, described in the formula (1). The compound described in the formula (2) as a starting material is subjected to the following series of reactions, and finally the compound, namely Sitagliptin, described in the formula (1) is prepared. Compared with the prior art in which a lot of Sitagliptin synthesizing steps exist and the synthesizing technology is complex, the synthesizing method is simple and easy to implement, low in cost, high in yield, good in product quality and suitable for large-scale industrial production.

INTERMEDIATES OF SITAGLIPTIN AND PREPARATION PROCESS THEREOF

Disclosed are intermediates of Sitagliptin, a preparation process thereof, and a process for synthesizing Sitagliptin using these intermediates. Sitagliptin is synthesized by using chiral amino compounds as a raw material, without having to build a chiral center with a chiral asymmetric catalytic hydrogenation, and high-pressure hydrogenation is avoided.