In vitro and in vivo efficacy and in vitro metabolism of 1-phenyl-3-aryl-2-propen-1-ones against Plasmodium falciparum
Investigation of a series of 1-phenyl-3-aryl-2-propen-1-ones resulted in the identification of nine inhibitors with submicromolar efficacy against at least one Plasmodium falciparum strain in vitro. These inhibitors were inactive when given orally in a Pl
Gutteridge, Clare E.,Nichols, Daniel A.,Curtis, Sean M.,Thota, Darshan S.,Vo, Joseph V.,Gerena, Lucia,Montip, Gettayacamin,Asher, Constance O.,Diaz, Damaris S.,DiTusa, Charles A.,Smith, Kirsten S.,Bhattacharjee, Apurba K.
Rapid Construction of Structurally Diverse Quinolizidines, Indolizidines, and Their Analogues via Ruthenium-Catalyzed Asymmetric Cascade Hydrogenation/Reductive Amination
A rapid construction of enantioenriched benzo-fused quinolizidines, indolizidines, and their analogues by ruthenium-catalyzed asymmetric cascade hydrogenation/reductive amination of quinolinyl- and quinoxalinyl-containing ketones has been developed. This