4401-04-1Relevant articles and documents
In vitro and in vivo efficacy and in vitro metabolism of 1-phenyl-3-aryl-2-propen-1-ones against Plasmodium falciparum
Gutteridge, Clare E.,Nichols, Daniel A.,Curtis, Sean M.,Thota, Darshan S.,Vo, Joseph V.,Gerena, Lucia,Montip, Gettayacamin,Asher, Constance O.,Diaz, Damaris S.,DiTusa, Charles A.,Smith, Kirsten S.,Bhattacharjee, Apurba K.
, p. 5682 - 5686 (2006)
Investigation of a series of 1-phenyl-3-aryl-2-propen-1-ones resulted in the identification of nine inhibitors with submicromolar efficacy against at least one Plasmodium falciparum strain in vitro. These inhibitors were inactive when given orally in a Pl
