Efficient enantioselective synthesis of piperidines through catalytic asymmetric ring-opening/cross-metathesis reactions
Mo the better! Chiral Mo complexes promote highly efficient asymmetric ring-opening/cross-metathesis reactions that afford functionalized piperidines in high E:Z selectivity and enantiomeric purity (see scheme for example; TBS = tert-butyldimethylsilyl).
Cortez, G. Alex,Schrock, Richard R.,Hoveyda, Amir H.
p. 4534 - 4538
(2008/09/17)
Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters
A series of des-keto lobeline analogs has been synthesized and evaluated for their ability to inhibit the dopamine transporter (DAT) and serotonin transporter (SERT) function and for their affinity for the synaptic vesicle monoamine transporter (VMAT2), a
Zheng, Guangrong,Horton, David B.,Deaciuc, Agripina G.,Dwoskin, Linda P.,Crooks, Peter A.
p. 5018 - 5021
(2007/10/03)
Lobeline: Structure-affinity investigation of nicotinic acetylcholinergic receptor binding
(-)Lobeline (1) and (-)nicotine (2) bind at neuronal nicotinic cholinergic (nACh) receptors with high affinity (K1 = 4 and 2 nM, respectively). Previous attempts to determine whether lobeline fits the currently accepted nicotinic pharmacophore
Flammia, Dwight,Dukat, Malgorzata,Damaj, M. Imad,Martin, Billy,Glennon, Richard A.
p. 3726 - 3731
(2007/10/03)
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