- Unraveling the structure-activity relationship of tomatidine, a steroid alkaloid with unique antibiotic properties against persistent forms of Staphylococcus aureus
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Staphylococcus aureus (S. aureus) is responsible for difficult-to-treat and relapsing infections and constitutes one of the most problematic pathogens due to its multiple resistances to clinically available antibiotics. Additionally, the ability of S. aureus to develop small-colony variants is associated with a reduced susceptibility to aminoglycoside antibiotics and in vivo persistence. We have recently demonstrated that tomatidine, a steroid alkaloid isolated from tomato plants, possesses anti-virulence activity against normal strains of S. aureus as well as the ability to potentiate the effect of aminoglycoside antibiotics. In addition, tomatidine has shown antibiotic activity against small-colony variants of S. aureus. We herein report the first study of the structure-activity relationship of tomatidine against S. aureus.
- Chagnon, Félix,Guay, Isabelle,Bonin, Marc-André,Mitchell, Gabriel,Bouarab, Kamal,Malouin, Fran?ois,Marsault, éric
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p. 605 - 620
(2014/06/23)
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- HELIX 12 DIRECTED STEROIDAL PHARMACEUTICAL PRODUCTS
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Compounds having the structure or their salts: are used to treat or reduce le likelihood of acquiring androgen-dependent diseases, such as prostate cancer, benign prostatic hyperplasia, polycystic ovarian syndrome, acne, hirsutism, seborrhea, androgenic alopecia and male baldness. They can be formulated together with pharmaceutically acceptable diluent or carrier or otherwise made into any pharmaceutical dosage form. Some of these compounds having tissue-specific antiandrogenic activity and tissue-specific androgenic activity can be used to treat or reduce the risk of developing diseases related to loss of androgenic stimulation. Combinations with other active pharmaceutical agents are also disclosed.
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Page/Page column 139
(2010/02/12)
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- Acetoxylation reactions of 17α, 21-dichloro-20-oxopregnanes and their relatives
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Acetoxylation reactions of 17a,21-dichloro-20-oxopregnanes and their relatives under different conditions using anhydrous sodium and potassium acetate are being studied in order to produce cortisone of triamcinolone side chain.
- Hazarika, Saroj,Goswami, Papori,Chowdhury, Pritish
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p. 1706 - 1710
(2007/10/03)
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