906-83-2 Usage
Description
ALLOPREGNANOLONE ACETATE, also known as 5α-Pregnan-3β-ol-20-one 3β-Acetate, is a derivative of Pregnenolone (P712200), a steroid hormone that plays a crucial role in the synthesis of various other steroid hormones, including progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. It functions as a prohormone and has been identified as a GABAA antagonist, which contributes to its neuromodulatory effects. Additionally, ALLOPREGNANOLONE ACETATE is known to enhance neurogenesis in the hippocampus and modulate the activity of cytochrome P 450-3A.
Uses
Used in Pharmaceutical Industry:
ALLOPREGNANOLONE ACETATE is used as a prohormone for its involvement in the production of essential steroid hormones, which are vital for various physiological processes in the human body.
Used in Neurological Applications:
ALLOPREGNANOLONE ACETATE is used as a GABAA antagonist for its neuromodulatory effects, which can influence the activity of the central nervous system and potentially contribute to the treatment of neurological disorders.
Used in Neurogenesis Promotion:
ALLOPREGNANOLONE ACETATE is used as a neurogenesis promoter in the hippocampus, which may have implications for the treatment of conditions associated with cognitive decline or memory impairment.
Used in Cytochrome P 450-3A Modulation:
ALLOPREGNANOLONE ACETATE is used as a modulator of cytochrome P 450-3A, an enzyme that plays a significant role in the metabolism of various drugs and substances, potentially impacting drug efficacy and safety.
Check Digit Verification of cas no
The CAS Registry Mumber 906-83-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 9,0 and 6 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 906-83:
(5*9)+(4*0)+(3*6)+(2*8)+(1*3)=82
82 % 10 = 2
So 906-83-2 is a valid CAS Registry Number.
InChI:InChI=1/C23H36O3/c1-14(24)19-7-8-20-18-6-5-16-13-17(26-15(2)25)9-11-22(16,3)21(18)10-12-23(19,20)4/h16-21H,5-13H2,1-4H3/t16-,17-,18-,19-,20-,21-,22-,23+/m0/s1
906-83-2Relevant articles and documents
Unraveling the structure-activity relationship of tomatidine, a steroid alkaloid with unique antibiotic properties against persistent forms of Staphylococcus aureus
Chagnon, Félix,Guay, Isabelle,Bonin, Marc-André,Mitchell, Gabriel,Bouarab, Kamal,Malouin, Fran?ois,Marsault, éric
, p. 605 - 620 (2014/06/23)
Staphylococcus aureus (S. aureus) is responsible for difficult-to-treat and relapsing infections and constitutes one of the most problematic pathogens due to its multiple resistances to clinically available antibiotics. Additionally, the ability of S. aureus to develop small-colony variants is associated with a reduced susceptibility to aminoglycoside antibiotics and in vivo persistence. We have recently demonstrated that tomatidine, a steroid alkaloid isolated from tomato plants, possesses anti-virulence activity against normal strains of S. aureus as well as the ability to potentiate the effect of aminoglycoside antibiotics. In addition, tomatidine has shown antibiotic activity against small-colony variants of S. aureus. We herein report the first study of the structure-activity relationship of tomatidine against S. aureus.
Acetoxylation reactions of 17α, 21-dichloro-20-oxopregnanes and their relatives
Hazarika, Saroj,Goswami, Papori,Chowdhury, Pritish
, p. 1706 - 1710 (2007/10/03)
Acetoxylation reactions of 17a,21-dichloro-20-oxopregnanes and their relatives under different conditions using anhydrous sodium and potassium acetate are being studied in order to produce cortisone of triamcinolone side chain.
