- Synthesis method of triazinopyrrole formic acid
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The invention discloses a synthesis method of triazinopyrrole formic acid, which comprises the following specific steps: (1) by taking a compound II as a raw material, heating and reacting in concentrated sulfuric acid to obtain an intermediate III; (2) carrying out ring closing reaction on the intermediate III and ethyl bromopyruvate to obtain an intermediate IV; and (3) hydrolyzing the intermediate IV in the presence of hydrochloric acid to obtain a target product, namely the compound I. The synthesis method disclosed by the invention is simple to operate, relatively high in yield and suitable for industrial production, and enriches the obtaining way of the fused ring compound.
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Paragraph 0024-0026; 0030-0032; 0035-0037
(2021/11/10)
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- Retro-ene reactions in heterocyclic synthesis. V. A novel synthetic method for 1,3,5-triazine-2,4(1H,3H)-diones
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(Chemical Equation Presented) N-t-Butylamidines 1 on heating with diphenyl carbonate (2) at 150-180° gave the 1,3,5-triazine-2,4(1H,3H)-dione derivatives 5. Acylation of amidines 1 and cyclocondensation of the resulting carbamates 3 gave [1,3,5,7]tetrazocine-2,6-dione derivatives 4, and subsequent retro-ene reaction and ring contraction afforded triazine derivatives 5.
- Ito, Kunio,Sekiguchi, Chiharu,Miida, Asuka Wakai Hiroyuki,Ihara, Shogo
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p. 1533 - 1535
(2008/09/18)
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