651310-21-3

Basic information

• Product Name: 5-Isoquinolinamine,4-chloro-(9CI)
• Synonyms: 5-Isoquinolinamine,4-chloro-(9CI);4-Chloroisoquinolin-5-aMine
• CAS NO: 651310-21-3
• Molecular Formula: C₉H₇ClN₂
• Molecular Weight: 178.61828
• Product Categories: ISOQUINOLINE
• Mol File: 651310-21-3.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-Isoquinolinamine,4-chloro-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Isoquinolinamine,4-chloro-(9CI)(651310-21-3)
• EPA Substance Registry System: 5-Isoquinolinamine,4-chloro-(9CI)(651310-21-3)

Safety Data

• Hazardous Substances Data: 651310-21-3(Hazardous Substances Data)

Usage

General Description

5-Isoquinolinamine,4-chloro-(9CI) is a chemical compound with the molecular formula C9H6ClN. It is a derivative of isoquinoline and contains a chlorine atom bonded to the fourth carbon atom of the isoquinoline ring. 5-Isoquinolinamine,4-chloro-(9CI) is primarily used in research and development as a building block for the synthesis of various pharmaceuticals and other organic compounds. It has also been studied for its potential biological activities, including anti-inflammatory and antitumor properties. However, there is limited information available on its specific uses and applications, and further research is needed to fully understand its potential uses.

Upstream product

• 1532-91-8 4-chloroisoquinoline 
• 53599-88-5 4-chloro-5-nitroisoquinoline 

Downstream Products

• 194032-34-3 4-chloroisoquinoline-5-sulfonyl chloride 

Relevant articles and documents

ROCK KINASE INHIBITORS

The present invention relates to compounds that inhibit ROCK activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of inhibiting ROCK activity and methods for treating, for example cerebral cavernous malformation syndrome (CCM) and cardiovascular diseases using the compounds and pharmaceutical compositions of the present invention.

SULFONAMIDE COMPOUND

A compound represented by the formula (1) [A represents a nitrogen-containing saturated ring; m represents an integer of 0 to 2; n represents an integer of 1 to 4; G1 represents hydrogen atom, chlorine atom, hydroxyl group, an alkoxy group, or amino group; G2 represents a halogen atom, hydroxyl group, cyano group, carboxy group, an alkyl group, an alkenyl group, and the like; G3 represents hydrogen atom, a halogen atom, hydroxyl group, cyano group, carboxy group, an alkyl group, an alkenyl group, and the like; G4 represents hydroxyl group, or —N(R1)(R2) (R1 and R2 represent hydrogen atom, an alkyl group, an aralkyl group, an alkenyl group, an alkynyl group, or a saturated heterocyclic group); G5 is a substituent on a ring-constituting carbon atom of A, and represents hydrogen atom, fluorine atom, or an alkyl group] or a salt thereof, or a derivative thereof that is a prodrug, which potently inhibits Rho kinase.

Sulfonamide compound

A compound represented by the formula (1) [A represents a nitrogen-containing saturated ring; m represents an integer of 0 to 2; n represents an integer of 1 to 4; G1 represents hydrogen atom, chlorine atom, hydroxyl group, an alkoxy group, or amino group; G2 represents a halogen atom, hydroxyl group, cyano group, carboxy group, an alkyl group, an alkenyl group, and the like; G3 represents hydrogen atom, a halogen atom, hydroxyl group, cyano group, carboxy group, an alkyl group, an alkenyl group, and the like; G4 represents hydroxyl group, or —N(R1)(R2) (R1 and R2 represent hydrogen atom, an alkyl group, an aralkyl group, an alkenyl group, an alkynyl group, or a saturated heterocyclic group); G5 is a substituent on a ring-constituting carbon atom of A, and represents hydrogen atom, fluorine atom, or an alkyl group] or a salt thereof, or a derivative thereof that is a prodrug, which potently inhibits phosphorylation of the myosin regulatory light chain.