2-amino-N,N-dimethylbenzamide

Base Information

• Chemical Name: 2-amino-N,N-dimethylbenzamide
• CAS No.: 6526-66-5
• Molecular Formula: C9H12N2O
• Molecular Weight: 164.207
• Hs Code.: 2924299090
• European Community (EC) Number: 819-076-9
• UNII: 074472898D
• ChEMBL ID: CHEMBL2263133
• DSSTox Substance ID: DTXSID10406493
• Wikidata: Q27236261
• Mol file: 6526-66-5.mol

Synonyms:2-amino-N,N-dimethylbenzamide;6526-66-5;2-Amino-N,N-dimethyl-benzamide;Benzamide, 2-amino-N,N-dimethyl-;N,N-Dimethyl-2-aminobenzamide;o-Amino-N,N-dimethylbenzamide;074472898D;UNII-074472898D;Oprea1_092698;o-Amino-N,N-dimethylbenzamid;SCHEMBL538290;F3034-0098;CHEMBL2263133;DTXSID10406493;DPXIIVXPZPOINE-UHFFFAOYSA-N;MFCD01168906;AKOS000111617;BF-0772;2-diethylaminoethyl4-amino-2-chloro-benzoate;BB 0242956;CS-0071466;FT-0678123;EN300-35807;A50814;A847041;J-508058;Q27236261;Z57825373

Chemical Property of 2-amino-N,N-dimethylbenzamide

Chemical Property:

• Vapor Pressure: 0.000147mmHg at 25°C
• Boiling Point: 332.3oC at 760 mmHg
• Flash Point: 154.8oC
• PSA: 46.33000
• Density: 1.116g/cm3
• LogP: 1.55180
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 164.094963011
• Heavy Atom Count: 12
• Complexity: 168

Purity/Quality:

99%, ^*data from raw suppliers

2-Amino-N,N-dimethylbenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)C(=O)C1=CC=CC=C1N

Technology Process of 2-amino-N,N-dimethylbenzamide

There total 12 articles about 2-amino-N,N-dimethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.4%

isatoic anhydride (118-48-9) + dimethyl amine (124-40-3) → 2-amino-N,N-dimethylbenzamide (6526-66-5)

Guidance literature:

In ethanol; water; at 25 ℃; for 2h;

DOI:10.1016/j.bmc.2021.116108

Reference yield: 99.4%

→ 2-amino-N,N-dimethylbenzamide (6526-66-5)

Guidance literature:

In ethanol; water; at 20 ℃; for 0.333333h;

Reference yield: 93.0%

N,N-dimethyl-2-nitrobenzamide (2018-71-5) → 2-amino-N,N-dimethylbenzamide (6526-66-5)

Guidance literature:

With copper acetylacetonate; sodium tetrahydroborate; In ethanol; for 2h; Ambient temperature;

upstream raw materials:

dimethyl amine

2-aminobenzoyl chloride

lithium dimethylamide

2-carbomethoxyaniline

Downstream raw materials:

2-((5-chloro-2-((4-((4-methylpiperazin-1-yl)methyl)phenyl)amino)pyrimidin-4-yl)amino)-N,N-dimethylbenzamide

2-((2-chloro-5-(trifluoromethyl)pyrimidin-4-yl)amino)-N,N-dimethylbenzamide

N,N-dimethyl-2-((2-((4-((4-methylpiperazin-1-yl)methyl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)benzamide

N-(methoxymethyl)-N-methylbenzamide

Refernces

• 1、 Polina, Saibabu,Putta, V. P. Rama Kishore,Gujjarappa, Raghuram,Singh, Virender,Pujar, Prasad Pralhad,Malakar, Chandi C.. "P(III)-Mediated Cascade C-N/C-S Bond Formation: A Protocol towards the Synthesis of N,S-Heterocycles and Spiro Compounds". . p. 431 - 445. Retrieved 2020/12/07.
• 2、 Mohammad, Akbar,Chandra, Prakash,Ghosh, Topi,Carraro, Mauro,Mobin, Shaikh M.. "Facile Access to Amides from Oxygenated or Unsaturated Organic Compounds by Metal Oxide Nanocatalysts Derived from Single-Source Molecular Precursors". . p. 10596 - 10608. Retrieved 2017/09/12.