H-THR-NH2 HCL

Base Information

• Chemical Name: H-THR-NH2 HCL
• CAS No.: 33209-01-7
• Molecular Formula: C4H11ClN2O2
• Molecular Weight: 154.597
• Hs Code.: 2924199090
• Mol file: 33209-01-7.mol

Synonyms:Butanamide,2-amino-3-hydroxy-, monohydrochloride, (2S,3R)- (9CI);Butanamide, 2-amino-3-hydroxy-,monohydrochloride, [R-(R*,S*)]-;Threoninamide, monohydrochloride, L- (8CI);

Chemical Property of H-THR-NH2 HCL

Chemical Property:

• Appearance/Colour: White to off white powder
• Vapor Pressure: 1.65E-07mmHg at 25°C
• Boiling Point: 384.9°C at 760 mmHg
• Flash Point: 186.6°C
• PSA: 89.34000
• LogP: 0.38240
• Storage Temp.: Store at RT.

Purity/Quality:

98%min ^*data from raw suppliers

L-Threonine amide hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: L-Threonine Amide Hydrochloride is used as a reagent in the synthesis of N-monosubstituted [(pyridin-2-yl)methyl]amine and [(pyrimidin-4-yl)methyl]amine derivatives as transient receptor potential cation channel 3 (TRPV3) modulators.

Technology Process of H-THR-NH2 HCL

There total 3 articles about H-THR-NH2 HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

L-threonine methyl ester hydrochloride (60143-52-4,71264-40-9,82650-07-5,97347-46-1,100157-61-7) → L-threonine amide hydrochloride (33209-01-7)

Guidance literature:

With hexamethylphosphorous triamide dichloride; ammonia; In dichloromethane; 1) 30 min, -20 deg C, 2) 4 h, r.t.;

Reference yield: 93.5%

benzyl ((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)carbamate (49705-98-8) → L-threonine amide hydrochloride (33209-01-7)

Guidance literature:

benzyl ((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)carbamate; With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 12h; under 7500.75 Torr;

With hydrogenchloride; In isopropyl alcohol; acetone; at 0 - 5 ℃;

DOI:10.3390/molecules23050996

Reference yield:

(2S,3R)-2-amino-3-hydroxybutanamide (49705-99-9) → L-threonine amide hydrochloride (33209-01-7)

Guidance literature:

With hydrogenchloride; In isopropyl alcohol; at 20 ℃;

upstream raw materials:

L-threonine methyl ester hydrochloride

(2S,3R)-2-amino-3-hydroxybutanamide

benzyl ((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)carbamate

Downstream raw materials:

[(S)-5-Benzoylamino-1-((1S,2R)-1-carbamoyl-2-hydroxy-propylcarbamoyl)-pentyl]-carbamic acid tert-butyl ester

[(S)-5-(4-Benzoyl-benzoylamino)-1-((1S,2R)-1-carbamoyl-2-hydroxy-propylcarbamoyl)-pentyl]-carbamic acid tert-butyl ester

benzyl ((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)carbamate

Boc-Tyr-Thr-NH₂

Refernces

• 1、 -. "Preparation of amino acid amides". Page/Page column 2. . Retrieved 2008/06/13.