Tramadol

Base Information Edit

Chemical Name:Tramadol
CAS No.:27203-92-5
Deprecated CAS:73806-46-9,113683-92-4,46941-74-6,113683-92-4
Molecular Formula:C₁₆H₂₅NO₂
Molecular Weight:263.38
Hs Code.:
European Community (EC) Number:248-319-6
UNII:39J1LGJ30J,0NG5TTM63P
DSSTox Substance ID:DTXSID90858931,DTXSID401167150
Nikkaji Number:J28.136K
Wikipedia:Tramadol
Wikidata:Q407592
NCI Thesaurus Code:C29507
RXCUI:10689
Pharos Ligand ID:62M1Y1V4ZP1L
Metabolomics Workbench ID:42601
ChEMBL ID:CHEMBL1066
Mol file:27203-92-5.mol

Synonyms:Adolonta;Amadol;Biodalgic;Biokanol;Contramal;Jutadol;K 315;K-315;K315;MTW Tramadol;MTW-Tramadol;MTWTramadol;Nobligan;Prontofort;Ranitidin 1A Pharma;Takadol;Theradol;Tiral;Topalgic;Tradol;Tradol Puren;Tradol-Puren;TradolPuren;Tradonal;Tralgiol;Trama 1A Pharma;Trama AbZ;Trama Dorsch;Trama KD;Trama-Dorsch;Tramabeta;Tramadin;Tramadoc;Tramadol;Tramadol 1A;Tramadol acis;Tramadol AL;Tramadol Asta Medica;Tramadol Basics;Tramadol Bayvit;Tramadol Bexal;Tramadol Cinfa;Tramadol Dolgit;Tramadol Edigen;Tramadol Hameln;Tramadol Heumann;Tramadol Hydrochloride;Tramadol Kern;Tramadol Lichtenstein;Tramadol Lindo;Tramadol Mabo;Tramadol Normon;Tramadol PB;Tramadol Ratiopharm;Tramadol Stada;Tramadol-Dolgit;Tramadol-Hameln;Tramadol-ratiopharm;TramadolDolgit;TramadolHameln;Tramadolor;Tramadolratiopharm;TramaDorsch;Tramadura;Tramagetic;Tramagit;Tramake;Tramal;Tramex;Tramundin;Trasedal;Ultram;Xymel 50;Zamudol;Zumalgic;Zydol;Zytram

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Tramadol Edit

Chemical Property:

Appearance/Colour:Light yellow oil
Melting Point:178-181 °C
Refractive Index:1.4909 (estimate)
Boiling Point:388.1 °C at 760 mmHg
PKA:14.47±0.40(Predicted)
Flash Point:188.5 °C
Density:1.047 g/cm³
Storage Temp.:2-8°C
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:263.188529040
Heavy Atom Count:19
Complexity:282

Purity/Quality:

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22

MSDS Files:: SDS file from LookChem

Useful:

Drug Classes:Opioids
Canonical SMILES:CN(C)CC1CCCCC1(C2=CC(=CC=C2)OC)O
Isomeric SMILES:CN(C)C[C@H]1CCCC[C@@]1(C2=CC(=CC=C2)OC)O
Recent ClinicalTrials:'NSAIDs vs. Opiates: Which is More Effective in Managing Pain in Mild to Moderate Acute Pancreatitis?
Recent EU Clinical Trials:Multicentre, randomized, open-label study to prove an additional
Recent NIPH Clinical Trials:The psychotropic drug dopamine PET study
Uses Tramadol is thought to produce analgesia by two distinct actions. First, it has agonist activity at the MOP and KOP receptors. Tramadol itself is a prodrug, with most of its analgesia mediated by a metabolite – O-desmethyltramadol – that has a 200-fold higher affinity for the MOP receptor. I t is metabolised by cytochrome P450 (CYP2D6 and CYP3A4), and its potency is therefore affected by a patient's CYP genetics, with rapid and poor metabolisers. S econd, it enhances the descending inhibitory systems in the spinal cord by inhibiting noradrenaline reuptake and releasing serotonin from nerve endings. It is available in immediate- and sustained-release oral preparations and for parenteral administration. I ts use is contraindicated in patients receiving monoamine oxidase inhibitors (MAOIs). Caution must also be exercised in hepatic impairment as its clearance is reduced to a much greater extent than morphine and related agents. An Analgesic. Used in the treatment of urinary incontinence
Therapeutic Function Analgesic

Technology Process of Tramadol

There total 34 articles about Tramadol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%