Atorvastatin Cyclic (Fluorophenyl) Impurity

Base Information

• Chemical Name: Atorvastatin Cyclic (Fluorophenyl) Impurity
• CAS No.: 873950-18-6
• Molecular Formula: C₃₃H₃₅FN₂O₇
• Molecular Weight: 590.649
• Mol file: 873950-18-6.mol

Synonyms:Atorvastatin Cyclic (Fluorophenyl) Sodium Salt Impurity;

Chemical Property of Atorvastatin Cyclic (Fluorophenyl) Impurity

Chemical Property:

• Melting Point: 157-161°C
• Boiling Point: 785.8±60.0 °C(Predicted)
• PKA: 4.35±0.10(Predicted)
• PSA: 131.86000
• Density: 1.42±0.1 g/cm3(Predicted)
• LogP: 3.96740
• Storage Temp.: -20°C Freezer
• Solubility.: Methanol (Slightly), Water (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

ATORVASTATIN CYCLIC(FLUOROPHENYL)SODIUM SALT IMPURITY 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1b-(4-Fluorophenyl)hexahydro-β,7-dihydroxy-7-(1-methylethyl)-1a-phenyl-7a-[(phenylamino)carbonyl]-3H-oxireno[3,4]pyrrolo[2,1-b][1,3]oxazine-3-butanoic Acid is an analyte in the simultaneous quantitative determination of metoprolol, atorvastatin and ramipril. A photodegadation product of Atorvastatin (a cyclic impurity of Atorvastatin).

Technology Process of Atorvastatin Cyclic (Fluorophenyl) Impurity

There total 2 articles about Atorvastatin Cyclic (Fluorophenyl) Impurity which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

atorvastatin (134523-00-5,110862-48-1) → 4-[1b-(4-fluoro-phenyl)-6-hydroxy-6-isopropyl-1a-phenyl-6a-phenylcarbamoyl-hexahydro-1,2-dioxa-5a-aza-cyclopropa[a]inden-3-yl]-3-(R)-hydroxy-butyric acid (873950-18-6)

Guidance literature:

With sodium hydroxide; dihydrogen peroxide; In water; acetonitrile; at 55 ℃; for 5h;

Reference yield:

lipitor (134523-03-8) → 4-(4-fluoro-phenyl)-2,4-dihydroxy-2-isopropyl-5-phenyl-3,6-dioxa-bicyclo[3.1.0]hexane-1-carboxylic acid phenylamide (873950-19-7) + 4-[1b-(4-fluoro-phenyl)-6-hydroxy-6-isopropyl-1a-phenyl-6a-phenylcarbamoyl-hexahydro-1,2-dioxa-5a-aza-cyclopropa[a]inden-3-yl]-3-(R)-hydroxy-butyric acid (873950-18-6) + 4-[6-(4-fluoro-phenyl)-6-hydroxy-1b-isopropyl-6a-phenyl-1a-phenylcarbamoyl-hexahydro-1,2-dioxa-5a-aza-cyclopropa[a]inden-3-yl]-3-(R)-hydroxy-butyric acid (873950-17-5) + 3-<(4-fluorophenyl)carbonyl>-2-(2-methyl-1-oxopropyl)-N,3-diphenyl-2-oxiranecarboxamide (148146-51-4)

Guidance literature:

With oxygen; at 80 ℃; for 720h;

upstream raw materials:

lipitor

atorvastatin

Refernces