Atorvastatin Cyclic (Isopropyl) Impurity

Base Information

• Chemical Name: Atorvastatin Cyclic (Isopropyl) Impurity
• CAS No.: 873950-17-5
• Molecular Formula: C33H35FN2O7
• Molecular Weight: 577.62000
• Mol file: 873950-17-5.mol

Synonyms:ATV-FXA sodium salt;7-(4-Fluorophenyl)hexahydro-β,7-dihydroxy-1b-(1-methylethyl)-7a-phenyl-1a-[(phenylamino)carbonyl]-3H-oxireno[3,4]pyrrolo[2,1-b][1,3]oxazine-3-butanoic Acid Sodium Salt;ATV-cycloIP Sodium Salt;4-(6-(4-fluorophenyl)-6-hydroxy-1b-isopropyl-6a-phenyl-1a-(phenylcarbamoyl)hexahydro-2l3-oxireno[2',3':3,4]pyrrolo[2,1-b]oxazol-2-yl)-3-hydroxybutanoic acid;

Chemical Property of Atorvastatin Cyclic (Isopropyl) Impurity

Chemical Property:

• Appearance/Colour: White to Off-White Solid
• Melting Point: >150°C (dec.)
• Boiling Point: 788.6±60.0 °C(Predicted)
• PKA: 4.35±0.10(Predicted)
• PSA: 131.86000
• Density: 1.42±0.1 g/cm3(Predicted)
• LogP: 3.35430

Purity/Quality:

> 95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Atorvastatin Cyclic (Isopropyl) Impurity

There total 2 articles about Atorvastatin Cyclic (Isopropyl) Impurity which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

atorvastatin (134523-00-5,110862-48-1) → 4-[6-(4-fluoro-phenyl)-6-hydroxy-1b-isopropyl-6a-phenyl-1a-phenylcarbamoyl-hexahydro-1,2-dioxa-5a-aza-cyclopropa[a]inden-3-yl]-3-(R)-hydroxy-butyric acid (873950-17-5)

Guidance literature:

atorvastatin; In water; acetonitrile; for 5h; Solar radiation;

With potassium hydroxide; In water; acetonitrile; pH=8 - 9;

Reference yield:

lipitor (134523-03-8) → 4-(4-fluoro-phenyl)-2,4-dihydroxy-2-isopropyl-5-phenyl-3,6-dioxa-bicyclo[3.1.0]hexane-1-carboxylic acid phenylamide (873950-19-7) + 4-[1b-(4-fluoro-phenyl)-6-hydroxy-6-isopropyl-1a-phenyl-6a-phenylcarbamoyl-hexahydro-1,2-dioxa-5a-aza-cyclopropa[a]inden-3-yl]-3-(R)-hydroxy-butyric acid (873950-18-6) + 4-[6-(4-fluoro-phenyl)-6-hydroxy-1b-isopropyl-6a-phenyl-1a-phenylcarbamoyl-hexahydro-1,2-dioxa-5a-aza-cyclopropa[a]inden-3-yl]-3-(R)-hydroxy-butyric acid (873950-17-5) + 3-<(4-fluorophenyl)carbonyl>-2-(2-methyl-1-oxopropyl)-N,3-diphenyl-2-oxiranecarboxamide (148146-51-4)

Guidance literature:

With oxygen; at 80 ℃; for 720h;

upstream raw materials:

lipitor

atorvastatin

Refernces