N-(4-Formamidophenyl)formamide

Base Information

• Chemical Name: N-(4-Formamidophenyl)formamide
• CAS No.: 6262-22-2
• Molecular Formula: C8H8N2O2
• Molecular Weight: 164.164
• DSSTox Substance ID: DTXSID20503982
• Nikkaji Number: J802.409J
• Wikidata: Q82358149
• Mol file: 6262-22-2.mol

Synonyms:6262-22-2;N-(4-FORMAMIDOPHENYL)FORMAMIDE;N,N'-(1,4-Phenylene)diformamide;1,4-Bis(formylamino)benzene;Diformyl-p-phenylendiamin;SCHEMBL469386;N,N'-1,4-Phenylenediformamide;DTXSID20503982;MFCD00723269;P2255

Chemical Property of N-(4-Formamidophenyl)formamide

Chemical Property:

• Melting Point: 211 °C
• PSA: 58.20000
• LogP: 2.24100
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 164.058577502
• Heavy Atom Count: 12
• Complexity: 135

Purity/Quality:

98%,99%, ^*data from raw suppliers

N,N'-(1,4-Phenylene)diformamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1NC=O)NC=O

Technology Process of N-(4-Formamidophenyl)formamide

There total 10 articles about N-(4-Formamidophenyl)formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-chlorophenyl formate (1988-22-3) + 1,4-phenylenediamine (106-50-3) → N-(4-formylaminophenyl)formamide (6262-22-2)

Guidance literature:

In neat (no solvent); at 20 ℃; for 2h;

DOI:10.1080/00397911.2016.1255334

Reference yield: 95.0%

1,4-phenylenediamine (106-50-3) + formic acid ethyl ester (109-94-4) → N-(4-formylaminophenyl)formamide (6262-22-2)

Guidance literature:

With acetic acid; for 24h; Reflux;

DOI:10.1016/j.tet.2009.01.038

Reference yield: 91.0%

formamide (77287-34-4,77287-35-5,60100-09-6) + 1,4-phenylenediamine (106-50-3) → N-(4-formylaminophenyl)formamide (6262-22-2)

Guidance literature:

at 150 ℃; for 24h; Sealed tube; Green chemistry;

DOI:10.1021/acs.orglett.8b03542

upstream raw materials:

formamide

acetic acid

1,4-phenylenediamine

para-dinitrobenzene

Downstream raw materials:

N,N'-dinitroso-N,N'-p-phenylene-bis-formamide

N,N'-dimethyl-p-phenylenediamine

C₂₀H₄Cl₁₂N₂S₂

1,4-phenylene diimidophosgene

Refernces

• 1、 Kumar Kar, Ashish,Srivastava, Rajendra. "Reductive Formylation of Nitroarenes using HCOOH over Bimetallic C?N Framework Derived from the Integration of MOF and COF". . p. 3174 - 3183. Retrieved 2021/05/27.
• 2、 -. "A non-catalyst non-promoter under the conditions of amide derivatives of aromatic amine with transfers the amine reaction". Paragraph 0063; 0064. . Retrieved 2019/03/28.