DL-Lysine monohydrochloride

Base Information

• Chemical Name: DL-Lysine monohydrochloride
• CAS No.: 70-53-1
• Deprecated CAS: 52377-94-3
• Molecular Formula: C6H14N2O2^.HCl
• Molecular Weight: 182.65
• Hs Code.: 29224100
• European Community (EC) Number: 200-739-0,245-258-7
• NSC Number: 206291,46705,9253
• UNII: 81478P92RJ
• DSSTox Substance ID: DTXSID601014484
• Wikidata: Q27269206
• Mol file: 70-53-1.mol

Synonyms:DL-Lysine monohydrochloride;70-53-1;2,6-diaminohexanoic acid hydrochloride;DL-LYSINE HYDROCHLORIDE;22834-80-6;Lysine hydrochloride, DL-;DL-Lysine, monohydrochloride;Lysine, hydrochloride (1:1);Lysine monohydrochloride;DL-lysine xhydrochloride;DL-Lysine HCl;Lysine monohydrochloride, dl-;DL-Lysine hydrochloride (VAN);UNII-81478P92RJ;L-Lysine-2-13C hydrochloride;NSC9253;EINECS 200-739-0;NSC 46705;NSC-46705;2,6-diaminohexanoic acid;hydrochloride;81478P92RJ;DL-2,6-diaminohexanoic acid hydrochloride;AI3-18306;Lysine, monohydrochloride;MFCD00064563;EC 200-739-0;C6H15ClN2O2;L-LYSINE-13C6 HCL 98 ATOM% 13C 95% CHE&;L-Lysine-6-13C hydrochloride;C5H12N2O2.xClH;UNII-1J3H6DC5PT;1J3H6DC5PT;C5-H12-N2-O2.x-Cl-H;EINECS 210-523-8;C6H14N2O2.ClH;MFCD00012920;NSC-206291;344298-93-7;LYSINE, (L);SCHEMBL41760;DL-Lysine, monohydrochlorid-;WLN: Z4YZVQ &GH -L;WLN: Z4YZVQ &QH -D;DTXSID601014484;LYSINE, DL-, HYDROCHLORIDE;NSC46705;2,3-Dihydro-5-benzofuranaceticAcid;AC7885;NSC206291;AKOS015847946;HY-W027251;2,6-Diamino-hexanoic acid;AS-13498;SY007003;AM20100661;CS-0071275;FT-0625536;FT-0627946;FT-0628058;FT-0657912;FT-0658876;L0070;DL-Lysine monohydrochloride, >=98% (HPLC);EN300-17974;D06469;A816381;Q-201027;Q27269206;F2191-0219

Chemical Property of DL-Lysine monohydrochloride

Chemical Property:

• Appearance/Colour: white crystalline powder
• Vapor Pressure: 0.000123mmHg at 25°C
• Melting Point: 267 °C
• Boiling Point: 311.5 °C at 760 mmHg
• Flash Point: 142.2 °C
• PSA: 89.34000
• Density: 1.125 g/cm3
• LogP: 1.72990
• Storage Temp.: Store at RT.
• Solubility.: H2O: soluble
• Water Solubility.: Soluble in water. Insoluble in ethanol, ethyl ether, acetone, benzene and common neutral solvents.
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 182.0822054
• Heavy Atom Count: 11
• Complexity: 106

Purity/Quality:

99% ^*data from raw suppliers

DL-Lysine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Biological Agents -> Amino Acids and Derivatives
• Canonical SMILES: C(CCN)CC(C(=O)O)N.Cl
• Recent EU Clinical Trials: Randomized phase III study comparing vinflunine-gemcitabine and gemcitabine-carboplatin combinations in patients ineligible to cisplatin with advanced or metastatic urothelial carcinoma.
• Uses: DL-Lysine monohydrochloride acts as an intermediate in the preparation of 3-amino-azepan-2-one. It also serves as an essential amino acid. It is used as animal feed. In addition to this, it is used in the construction of polylysine polymers, which finds application in lysine-based polypeptide gels and films.

Technology Process of DL-Lysine monohydrochloride

There total 6 articles about DL-Lysine monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.6%

D-lysine (923-27-3,3506-25-0) → D-lysine bis(hydrochloride) (70-53-1,617-68-5,657-26-1,657-27-2,7274-88-6,10098-89-2,10303-72-7,22834-80-6,28826-16-6,42334-88-3,68147-44-4,94706-35-1,26124-78-7)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; for 3h;

DOI:10.1021/acs.orglett.8b02619

Reference yield: 94.0%

(+/-)-3-(trans-2'-Nitrocyclopropyl)alanine hydrochloride → 2,6-diaminohexanoic acid hydrochloride (70-53-1,26124-78-7)

Guidance literature:

With hydrogen; palladium dichloride; In methanol; at 20 ℃; for 96h; under 750.06 Torr;

DOI:10.1070/MC2003v013n05ABEH001817

Reference yield: 93.3%

→ 2,6-diaminohexanoic acid hydrochloride (70-53-1,26124-78-7)

Guidance literature:

upstream raw materials:

L-lysine

D-lysine

α-nitrocaprolactam

2,6-Diamino-hexanoic acid; hydrochloride

Downstream raw materials:

2,6-Diamino-hexanoic acid; hydrochloride

ε-acetyllysine methyl ester hydrochloride

piperidine

2-Methylpiperidin

Refernces

• 1、 Octa-Smolin, Frescilia,Thiele, Maike,Yadav, Rohan,Platzek, André,Clever, Guido H.,Niemeyer, Jochen. "Chiral Receptors for Lysine Based on Covalently Linked Bis- and Tris-binaphthylphosphoric Acids". supporting information. p. 6153 - 6156. Retrieved 2018/10/05.
• 2、 Yamada, Shigeki,Hongo, Chikara,Yoshioka, Ryuzo,Chibata, Ichiro. "Method for the Racemization of Optically Active Amino Acids". . p. 843 - 846. Retrieved 2007/10/02.