L-ARGININE P-NITROANILIDE DIHYDROCHLORIDE

Base Information

• Chemical Name: L-ARGININE P-NITROANILIDE DIHYDROCHLORIDE
• CAS No.: 40127-11-5
• Molecular Formula: C₁₂H₁₈N₆O₃*2ClH
• Molecular Weight: 367.235
• Hs Code.: 2925290090
• Mol file: 40127-11-5.mol

Synonyms:Pentanamide,2-amino-5-[(aminoiminomethyl)amino]-N-(4-nitrophenyl)-, dihydrochloride, (S)-;L-Arginine p-nitroanilide dihydrochloride

Chemical Property of L-ARGININE P-NITROANILIDE DIHYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 1.03E-15mmHg at 25°C
• Boiling Point: 621.6oC at 760 mmHg
• Flash Point: 329.8oC
• PSA: 162.84000
• LogP: 4.21530
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

H-Arg-pNA 2HCl ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Specific substrate for cathepsin H. L-Arginine p-Nitroanilide Dihydrochloride can be used to prepare flavor peptide.

Technology Process of L-ARGININE P-NITROANILIDE DIHYDROCHLORIDE

There total 3 articles about L-ARGININE P-NITROANILIDE DIHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-(t-butoxycarbonyl)-L-arginine p-nitroanilide hydrochloride (99306-64-6) → L-arginine p-nitroanilide dihydrochloride (40127-11-5,75613-02-4)

Guidance literature:

With hydrogenchloride; In acetic acid; for 2h; Ambient temperature;

DOI:10.1246/bcsj.64.1422

Reference yield:

Nα-t-butoxycarbonyl-arginine hydrochloride (35897-34-8,113712-06-4) → L-arginine p-nitroanilide dihydrochloride (40127-11-5,75613-02-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / pyridine / 4 h / 40 °C

2: 96 percent / 2.17 M HCl / acetic acid / 2 h / Ambient temperature

With pyridine; hydrogenchloride; In acetic acid;

DOI:10.1246/bcsj.64.1422

Reference yield:

N,N'-bis(4-nitrophenyl)phospheneimidous amide (134393-23-0) → L-arginine p-nitroanilide dihydrochloride (40127-11-5,75613-02-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / pyridine / 4 h / 40 °C

2: 96 percent / 2.17 M HCl / acetic acid / 2 h / Ambient temperature

With pyridine; hydrogenchloride; In acetic acid;

DOI:10.1246/bcsj.64.1422

upstream raw materials:

N-(t-butoxycarbonyl)-L-arginine p-nitroanilide hydrochloride

N^α-t-butoxycarbonyl-arginine hydrochloride

N,N'-bis(4-nitrophenyl)phospheneimidous amide

Downstream raw materials:

2HCl*H-Gly-Arg-pNA

N-benzoyl-L-isoleucyl-L-α-glutamylglycyl-N-(4-nitrophenyl)-L-argininamide methyl ester hydrochloride

Refernces