2-Chloro-7-fluoroquinazoline

Base Information

• Chemical Name: 2-Chloro-7-fluoroquinazoline
• CAS No.: 956101-10-3
• Molecular Formula: C8H4ClFN2
• Molecular Weight: 182.585
• Hs Code.: 2933990090
• Mol file: 956101-10-3.mol

Synonyms:2-chloro-7-fluoroquinazoline;Quinazoline,2-chloro-7-fluoro-

Chemical Property of 2-Chloro-7-fluoroquinazoline

Chemical Property:

• Refractive Index: 1.634
• Boiling Point: 254.1 °C at 760 mmHg
• PKA: -0.25±0.30(Predicted)
• Flash Point: 107.5 °C
• PSA: 25.78000
• Density: 1.447 g/cm³
• LogP: 2.42230

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-7-fluoroquinazoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-7-fluoroquinazoline

There total 5 articles about 2-Chloro-7-fluoroquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-fluoro-2,4-dioxo-1,2,3,4-tetrahydroquinazoline (76088-98-7) → 2-chloro-7-fluoro-quinazoline (956101-10-3)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate; N,N-diethylaniline

2: zinc; ammonium hydroxide / dichloromethane

With ammonium hydroxide; N,N-diethylaniline; zinc; trichlorophosphate; In dichloromethane;

DOI:10.1248/cpb.c14-00264

Reference yield:

4-fluoroanthranilic acid (446-32-2) → 2-chloro-7-fluoro-quinazoline (956101-10-3)

Guidance literature:

Multi-step reaction with 5 steps

1: acetic acid / water / 6 h / 25 °C / Green chemistry; Large scale

2: sodium hydroxide / water / 4 h / Green chemistry; Large scale

3: hydrogenchloride / water / pH < 1 / Green chemistry; Large scale

4: trichlorophosphate; N,N-diethylaniline

5: zinc; ammonium hydroxide / dichloromethane

With hydrogenchloride; ammonium hydroxide; acetic acid; N,N-diethylaniline; sodium hydroxide; zinc; trichlorophosphate; In dichloromethane; water;

DOI:10.1248/cpb.c14-00264

Reference yield:

2,4,-dichloro-7-fluoroquinazoline (174566-15-5) → 2-chloro-7-fluoro-quinazoline (956101-10-3)

Guidance literature:

With ammonium hydroxide; zinc; In dichloromethane;

DOI:10.1248/cpb.c14-00264

upstream raw materials:

7-fluoro-2,4-dioxo-1,2,3,4-tetrahydroquinazoline

4-fluoroanthranilic acid

2,4,-dichloro-7-fluoroquinazoline

Downstream raw materials:

5-bromo-3-cyclopropyl-1-(trans-3-((7-fluoroquinazolin-2-yl)amino)cyclobutyl)-1H-imidazo[4,5-b]pyrazin-2(3H)-one

Refernces