Z-ALA-NH2

Base Information

• Chemical Name: Z-ALA-NH2
• CAS No.: 13139-27-0
• Molecular Formula: C11H14 N2 O3
• Molecular Weight: 222.244
• Hs Code.: 2924299090
• Mol file: 13139-27-0.mol

Synonyms:Carbamicacid, (1-carbamoylethyl)-, benzyl ester, L- (8CI); Carbamic acid, (2-amino-1-methyl-2-oxoethyl)-,phenylmethyl ester, (S)-; Carbamic acid, [(1S)-2-amino-1-methyl-2-oxoethyl]-,phenylmethyl ester (9CI); Alaninamide, N-carboxy-, benzyl ester, L-;N-Benzyloxycarbonylalanine amide

Chemical Property of Z-ALA-NH2

Chemical Property:

• PSA: 81.42000
• LogP: 1.87780
• Storage Temp.: Store at RT.

Purity/Quality:

98%,99%, ^*data from raw suppliers

Z-L-alanine amide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Z-ALA-NH2

There total 15 articles about Z-ALA-NH2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(S)-2-benzyloxycarbonylamino-propionic acid methyl ester (28819-05-8) → L-α-N-Cbz-alaninamide (13139-27-0)

Guidance literature:

With ammonia; In methanol; at 50 ℃; Sealed tube;

DOI:10.3390/molecules25061315

Reference yield: 96.0%

N-Cbz-Ala (1142-20-7) → L-α-N-Cbz-alaninamide (13139-27-0)

Guidance literature:

With ammonium hydroxide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.166667h; Ambient temperature;

Reference yield: 89.0%

(N-benzyloxycarbonyl)-L-alanine N-hydroxysuccinimide ester (3401-36-3) → L-α-N-Cbz-alaninamide (13139-27-0)

Guidance literature:

With ammonia; In methanol; at 20 ℃;

DOI:10.1002/hlca.201200451

upstream raw materials:

N-Cbz-Ala

L-alanine methyl ester hydrochloride

benzyl chloroformate

(S)-2-benzyloxycarbonylamino-propionic acid methyl ester

Downstream raw materials:

2'(S)-2-(2-benzyloxycarbonylaminopropionylamino)-3-oxobutyric acid methyl ester

C₁₉H₂₄N₂O₅

[(S)-1-(6-methoxy-[1,5]naphthyridin-4-ylcarbamoyl)-ethyl]-carbamic acid benzyl ester

((S)-2-amino-1-methyl-ethyl)-carbamic acid benzyl ester

Refernces

• 1、 Liu, Juan,Wang, Fei,Liu, Li-Yang,Zhang, Jian. "Interpenetrated Three-Dimensional Copper-Iodine Cluster-Based Framework with Enantiopure Porphyrin-like Templates". . p. 1358 - 1360. Retrieved 2016.
• 2、 Anderson, Rosaleen J.,Gray, Mark,Kondacs, Laszlo A.,Marrs, Emma C. L.,Orenga, Sylvain,Perry, John D.. "C-terminal 1-aminoethyltetrazole-containing oligopeptides as novel alanine racemase inhibitors". . . Retrieved 2020.
• 3、 -. "ANTIBACTERIAL COMPOUND AND USES OF SAME". Paragraph 0050. . Retrieved 2020/09/15.