2-(5-chloro-2-thienylthio)-4-fluorobenzyl alcohol

Base Information

• Chemical Name: 2-(5-chloro-2-thienylthio)-4-fluorobenzyl alcohol
• CAS No.: 81223-47-4
• Molecular Formula: C₁₁H₈ClFOS₂
• Molecular Weight: 274.767
• Mol file: 81223-47-4.mol

Synonyms:2-(5-chloro-2-thienylthio)-4-fluorobenzyl alcohol

Chemical Property of 2-(5-chloro-2-thienylthio)-4-fluorobenzyl alcohol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-(5-chloro-2-thienylthio)-4-fluorobenzyl alcohol

There total 4 articles about 2-(5-chloro-2-thienylthio)-4-fluorobenzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-fluoroanthranilic acid (446-32-2) → 2-(5-chloro-2-thienylthio)-4-fluorobenzyl alcohol (81223-47-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / LiAlH₄ / diethyl ether / 3 h / Heating

3: K₂CO₃ / Cu / 2.5 h / 120 - 130 °C

With lithium aluminium tetrahydride; potassium carbonate; copper; In diethyl ether;

DOI:10.1135/cccc19812222

Reference yield:

2,2’-disulfanediylbis(4-fluorobenzoic acid) (81223-41-8) → 2-(5-chloro-2-thienylthio)-4-fluorobenzyl alcohol (81223-47-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / LiAlH₄ / diethyl ether; tetrahydrofuran / 6 h / Heating

2: K₂CO₃ / Cu / 2.5 h / 120 - 130 °C

With lithium aluminium tetrahydride; potassium carbonate; copper; In tetrahydrofuran; diethyl ether;

DOI:10.1135/cccc19812222

Reference yield:

2-chloro-5-iodothiophene (28712-49-4) + 4-fluoro-2-mercaptobenzyl alcohol (81223-46-3) → 2-(5-chloro-2-thienylthio)-4-fluorobenzyl alcohol (81223-47-4)

Guidance literature:

With potassium carbonate; copper; at 120 - 130 ℃; for 2.5h; Yield given;

DOI:10.1135/cccc19812222

upstream raw materials:

2-chloro-5-iodothiophene

4-fluoro-2-mercaptobenzyl alcohol

4-fluoroanthranilic acid

(2-amino-4-fluorophenyl)methanol

Downstream raw materials:

<2-(5-chloro-2-thienylthio)-4-fluorophenyl>acetonitrile

<2-(5-chloro-2-thienylthio)-4-fluorophenyl>acetic acid

2-(5-chloro-2-thienylthio)-4-fluorobenzyl chloride

Refernces